Abstract
Acute respiratory distress syndrome (ARDS) in COVID-19 patients is associated with poor clinical outcomes and high mortality rates, despite the use of mechanical ventilation. Veno-Venous Extracorporeal membrane Oxygenation (VV-ECMO) in these patients is a viable salvage therapy. We describe clinical outcomes and survival rates in 52 COVID-19 patients with ARDS treated with early VV-ECMO at a large, high-volume center ECMO program. Outcomes included arterial blood gases, respiratory parameters, inflammatory markers, adverse events, and survival rates. Patients’ mean age was 47.8 ± 12.1 years, 33% were female, and 75% were Hispanic. At the end of study period, 56% (n = 29) of the patients survived and were discharged and 44% (n = 23) of the patients expired. Survival rate was 75.0% (9 out of 12) in patients placed on ECMO prior to mechanical ventilation. Longer duration on mechanical ventilation prior to ECMO intervention was associated with a 31% (aOR = 1.31, 95% CI, 1.00–1.70) increased odds of mortality after adjusting for age, gender, BMI, number of comorbid conditions, and post-ECMO ventilator days. Early and effective ECMO intervention in critical ill COVID-19 patients might be a valuable strategy in critical care settings to increase their odds of survival.
Original language | English (US) |
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Pages (from-to) | 861-867 |
Number of pages | 7 |
Journal | International Journal of Artificial Organs |
Volume | 44 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2021 |
Externally published | Yes |
Keywords
- ARDS
- COVID-19
- awake ECMO
- early ECMO
- mechanical ventilation
- mortality
- observational
ASJC Scopus subject areas
- Bioengineering
- Biomedical Engineering
- Medicine (miscellaneous)
- Biomaterials