Clinical outcomes of meningitis caused by Streptococcus pneumoniae in the era of antibiotic resistance

Anthony E. Fiore, John F. Moroney, Monica M. Farley, Lee H. Harrison, Jan E Patterson, James H. Jorgensen, Martin Cetron, Margarette S. Kolczak, Robert F. Breiman, Anne Schuchat

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Original languageEnglish
Pages (from-to)71-77
Number of pages7
JournalClinical Infectious Diseases
Volume30
Issue number1
DOIs
StatePublished - 2000

Fingerprint

Pneumococcal Meningitis
Cefotaxime
Microbial Drug Resistance
Vancomycin
Streptococcus pneumoniae
Intensive Care Units
Baltimore
Mortality
Long-Term Care
Cephalosporins
Meningitis
Intubation
Oxygen
Pharmaceutical Preparations
Population

ASJC Scopus subject areas

  • Immunology

Cite this

Fiore, A. E., Moroney, J. F., Farley, M. M., Harrison, L. H., Patterson, J. E., Jorgensen, J. H., ... Schuchat, A. (2000). Clinical outcomes of meningitis caused by Streptococcus pneumoniae in the era of antibiotic resistance. Clinical Infectious Diseases, 30(1), 71-77. https://doi.org/10.1086/313606

Clinical outcomes of meningitis caused by Streptococcus pneumoniae in the era of antibiotic resistance. / Fiore, Anthony E.; Moroney, John F.; Farley, Monica M.; Harrison, Lee H.; Patterson, Jan E; Jorgensen, James H.; Cetron, Martin; Kolczak, Margarette S.; Breiman, Robert F.; Schuchat, Anne.

In: Clinical Infectious Diseases, Vol. 30, No. 1, 2000, p. 71-77.

Research output: Contribution to journalArticle

Fiore, AE, Moroney, JF, Farley, MM, Harrison, LH, Patterson, JE, Jorgensen, JH, Cetron, M, Kolczak, MS, Breiman, RF & Schuchat, A 2000, 'Clinical outcomes of meningitis caused by Streptococcus pneumoniae in the era of antibiotic resistance', Clinical Infectious Diseases, vol. 30, no. 1, pp. 71-77. https://doi.org/10.1086/313606
Fiore, Anthony E. ; Moroney, John F. ; Farley, Monica M. ; Harrison, Lee H. ; Patterson, Jan E ; Jorgensen, James H. ; Cetron, Martin ; Kolczak, Margarette S. ; Breiman, Robert F. ; Schuchat, Anne. / Clinical outcomes of meningitis caused by Streptococcus pneumoniae in the era of antibiotic resistance. In: Clinical Infectious Diseases. 2000 ; Vol. 30, No. 1. pp. 71-77.
@article{c9b68b35c16b40e684021bbb4f27f060,
title = "Clinical outcomes of meningitis caused by Streptococcus pneumoniae in the era of antibiotic resistance",
abstract = "Limited data are available on clinical outcomes of meningitis due to cefotaxime-nonsusceptible Streptococcus pneumoniae. We analyzed data from 109 cases of pneumococcal meningitis in Atlanta, Baltimore, and San Antonio, which were identified through population-based active surveillance from November 1994 to April 1996. Pneumococcal isolates from 9{\%} of the cases were resistant to cefotaxime, and isolates from 11{\%} had intermediate susceptibility. Children were more likely to have cephalosporin- nonsusceptible pneumococcal meningitis, but mortality was significantly higher among adults aged 18-64 years. Vancomycin was given upon admission to 29{\%} of patients, and within 48 h of admission to 52{\%}. Nonsusceptibility to cefotaxime was not associated with the following outcomes: increased mortality, prolonged length of hospital or intensive care unit (ICU) stay, requirement of intubation or oxygen, ICU care, discharge to another medical or long-term-care facility, or neurological deficit. Empirical use of vancomycin, current prevalence of drug-resistant S. pneumoniae, and degree of nonsusceptibility to cefotaxime may have influenced these findings.",
author = "Fiore, {Anthony E.} and Moroney, {John F.} and Farley, {Monica M.} and Harrison, {Lee H.} and Patterson, {Jan E} and Jorgensen, {James H.} and Martin Cetron and Kolczak, {Margarette S.} and Breiman, {Robert F.} and Anne Schuchat",
year = "2000",
doi = "10.1086/313606",
language = "English",
volume = "30",
pages = "71--77",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "1",

}

TY - JOUR

T1 - Clinical outcomes of meningitis caused by Streptococcus pneumoniae in the era of antibiotic resistance

AU - Fiore, Anthony E.

AU - Moroney, John F.

AU - Farley, Monica M.

AU - Harrison, Lee H.

AU - Patterson, Jan E

AU - Jorgensen, James H.

AU - Cetron, Martin

AU - Kolczak, Margarette S.

AU - Breiman, Robert F.

AU - Schuchat, Anne

PY - 2000

Y1 - 2000

N2 - Limited data are available on clinical outcomes of meningitis due to cefotaxime-nonsusceptible Streptococcus pneumoniae. We analyzed data from 109 cases of pneumococcal meningitis in Atlanta, Baltimore, and San Antonio, which were identified through population-based active surveillance from November 1994 to April 1996. Pneumococcal isolates from 9% of the cases were resistant to cefotaxime, and isolates from 11% had intermediate susceptibility. Children were more likely to have cephalosporin- nonsusceptible pneumococcal meningitis, but mortality was significantly higher among adults aged 18-64 years. Vancomycin was given upon admission to 29% of patients, and within 48 h of admission to 52%. Nonsusceptibility to cefotaxime was not associated with the following outcomes: increased mortality, prolonged length of hospital or intensive care unit (ICU) stay, requirement of intubation or oxygen, ICU care, discharge to another medical or long-term-care facility, or neurological deficit. Empirical use of vancomycin, current prevalence of drug-resistant S. pneumoniae, and degree of nonsusceptibility to cefotaxime may have influenced these findings.

AB - Limited data are available on clinical outcomes of meningitis due to cefotaxime-nonsusceptible Streptococcus pneumoniae. We analyzed data from 109 cases of pneumococcal meningitis in Atlanta, Baltimore, and San Antonio, which were identified through population-based active surveillance from November 1994 to April 1996. Pneumococcal isolates from 9% of the cases were resistant to cefotaxime, and isolates from 11% had intermediate susceptibility. Children were more likely to have cephalosporin- nonsusceptible pneumococcal meningitis, but mortality was significantly higher among adults aged 18-64 years. Vancomycin was given upon admission to 29% of patients, and within 48 h of admission to 52%. Nonsusceptibility to cefotaxime was not associated with the following outcomes: increased mortality, prolonged length of hospital or intensive care unit (ICU) stay, requirement of intubation or oxygen, ICU care, discharge to another medical or long-term-care facility, or neurological deficit. Empirical use of vancomycin, current prevalence of drug-resistant S. pneumoniae, and degree of nonsusceptibility to cefotaxime may have influenced these findings.

UR - http://www.scopus.com/inward/record.url?scp=0033956697&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033956697&partnerID=8YFLogxK

U2 - 10.1086/313606

DO - 10.1086/313606

M3 - Article

C2 - 10619736

AN - SCOPUS:0033956697

VL - 30

SP - 71

EP - 77

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 1

ER -