Clinical-MRI correlations in a multiethnic cohort with recent lacunar stroke: The SPS3 trial

for the SPS3 Investigators

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Background: Neuroimaging manifestations of small vessel disease are heterogeneous, and correlation with patient features has not been adequately characterized. Aim: Our goal was to correlate magnetic resonance imaging findings with clinical features in a large multiethnic cohort with recent lacunar stroke. Methods: Patient characteristics were correlated with neuroimaging results in the Secondary Prevention of Small Subcortical Stroke study participants. Results: Among 3005 patients, mean age was 63 years; 62% were men; and 51%, 30%, and 16% were non-Hispanic White, Hispanic, and Black, respectively. Recent lacunar infarcts were distributed between the subcortical hemisphere (31%), thalamus (26%), brainstem/cerebellum (26%), and basal ganglia/internal capsule (16%). Multiple lacunar infarcts (i.e., acute and remote) were present in 40% and associated with increased age (OR 1·3 per 20 years, 95% CI 1·1, 1·5), male gender (OR 1·5, CI 1·3, 1·7), hypertension (OR 1·5, CI 1·2, 1·8), increased systolic blood pressure (OR 1·2 per 20mmHg, CI 1·1, 1·3), and prior stroke (OR 3·8, CI 2·9, 5·0). Moderate-severe white matter hyperintensities were present in 50% and associated with increased age (OR 4·3 per 20 years, CI 3·4, 5·4), hypertension (OR 1·8, CI 1·4, 2·3), increased systolic blood pressure (OR 1·3 per 20mmHg, CI 1·1, 1·5), increased diastolic blood pressure (OR 1·2 per 10mm, CI 1·0, 1·3), and prior stroke (OR 3·3, CI 2·3, 4·5). Infarct location varied significantly by race-ethnicity (P<0·001), with Blacks and Hispanics having more infarcts in the brainstem/cerebellum than non-Hispanic Whites, and by gender with women more often having thalamic lacunes than men (P≤0·001). Conclusions: In patients with recent lacunar stroke, infarct location and number have distinctie associations with gender, vascular risk factors, and race-ethnicity, demonstrating the complex pathogenesis of lacunar stroke and cerebral small artery disease.

Original languageEnglish (US)
Pages (from-to)1057-1064
Number of pages8
JournalInternational Journal of Stroke
Issue number8
StatePublished - Dec 1 2014


  • African American
  • Hispanics
  • Lacunar stroke
  • MRI
  • Small vessel disease
  • White matter hyperintensity

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


Dive into the research topics of 'Clinical-MRI correlations in a multiethnic cohort with recent lacunar stroke: The SPS3 trial'. Together they form a unique fingerprint.

Cite this