Clinical isolates of Mycobacterium simiae in San Antonio, Texas: An 11-yr review

Gustavo Valero, Jay Peters, James H. Jorgensen, John R. Graybill

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


During a period of 11 yr (1983-1993) 137 clinical isolates of Mycobacterium simiae obtained from 75 patients were identified in a University hospital in San Antonio, Texas. One hundred twenty-eight isolates (93%) were from a pulmonary source, four (3%) from blood, and five from other sites including skin, urine, lymph node, bone marrow, and brain. Of 62 evaluable patients, six (10%) had definite infection, nine (14%) had probable disease, and 48 (76%) were thought to be colonized. During the last 2 yr of the study (1992 and 1993), M. simiae became the second most frequently isolated non-tuberculous mycobacterium at this institution surpassed only by Mycobacterium avium complex. There are limited data about effective treatment for this multidrug-resistant organism. New macrolides, quinolones, ethambutol, clofazimine, and aminoglycosides are promising therapeutic agents.

Original languageEnglish (US)
Pages (from-to)1555-1557
Number of pages3
JournalAmerican Journal of Respiratory and Critical Care Medicine
Issue number5 I
StatePublished - Nov 1995

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


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