Clinical impact of selumetinib on pediatric elephantiasis neuromatosa

Kristina Blegen, Sara E. Ortiz-Romero, Olivia Juarez, Julie Voeller

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Elephantiasis neuromatosa (EN) is a rare and extreme form of plexiform neurofibroma in patients with neurofibromatosis type 1 (NF1). EN is often associated with significant morbidity and remains difficult to treat. We present a case of an 11-year-old female with NF1 whose thoracolumbar plexiform neurofibroma and lower extremity EN exhibited clinical improvement from treatment with selumetinib, a selective MEK inhibitor.

Original languageEnglish (US)
Pages (from-to)764-766
Number of pages3
JournalPediatric dermatology
Volume39
Issue number5
DOIs
StatePublished - Sep 1 2022
Externally publishedYes

Keywords

  • NF1
  • elephantiasis neuromatosa
  • neurofibromatosis
  • plexiform neurofibroma
  • selumetinib

ASJC Scopus subject areas

  • Dermatology
  • Pediatrics, Perinatology, and Child Health

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