Clinical, histologic, and genetic features of mesothelioma in a 7-Year-old child

Aaron Sugalski; Mary Davis; Latha Prasannan; Victor Saldivar; Jaclyn Y. Hung; Gail E. Tomlinson

doi:10.1002/pbc.24284

Clinical, histologic, and genetic features of mesothelioma in a 7-Year-old child

Aaron Sugalski, Mary Davis, Latha Prasannan, Victor Saldivar, Jaclyn Y. Hung, Gail E. Tomlinson

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Malignant mesothelioma (MM) is a highly aggressive malignancy that is extremely rare in children. This case report documents a 7-year-old male without previous asbestos exposure with peritoneal MM that initially responded to chemotherapy with cisplatin and gemcitabine but ultimately metastasized to his chest. He was diagnosed with MM based on histology, extensive immunohistochemical analyses, and an elevated serum CA-125 level. Cytogenetics and comparative genomic hybridization (CGH) analysis of his tumor identified a single extra copy number of chromosome 11 with few other changes noted.

Original language	English (US)
Pages (from-to)	146-148
Number of pages	3
Journal	Pediatric Blood and Cancer
Volume	60
Issue number	1
DOIs	https://doi.org/10.1002/pbc.24284
State	Published - Jan 2013

Keywords

Cancer genetics
Mesothelioma
Rare tumors

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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title = "Clinical, histologic, and genetic features of mesothelioma in a 7-Year-old child",

abstract = "Malignant mesothelioma (MM) is a highly aggressive malignancy that is extremely rare in children. This case report documents a 7-year-old male without previous asbestos exposure with peritoneal MM that initially responded to chemotherapy with cisplatin and gemcitabine but ultimately metastasized to his chest. He was diagnosed with MM based on histology, extensive immunohistochemical analyses, and an elevated serum CA-125 level. Cytogenetics and comparative genomic hybridization (CGH) analysis of his tumor identified a single extra copy number of chromosome 11 with few other changes noted.",

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AU - Prasannan, Latha

AU - Saldivar, Victor

AU - Hung, Jaclyn Y.

AU - Tomlinson, Gail E.

PY - 2013/1

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N2 - Malignant mesothelioma (MM) is a highly aggressive malignancy that is extremely rare in children. This case report documents a 7-year-old male without previous asbestos exposure with peritoneal MM that initially responded to chemotherapy with cisplatin and gemcitabine but ultimately metastasized to his chest. He was diagnosed with MM based on histology, extensive immunohistochemical analyses, and an elevated serum CA-125 level. Cytogenetics and comparative genomic hybridization (CGH) analysis of his tumor identified a single extra copy number of chromosome 11 with few other changes noted.

AB - Malignant mesothelioma (MM) is a highly aggressive malignancy that is extremely rare in children. This case report documents a 7-year-old male without previous asbestos exposure with peritoneal MM that initially responded to chemotherapy with cisplatin and gemcitabine but ultimately metastasized to his chest. He was diagnosed with MM based on histology, extensive immunohistochemical analyses, and an elevated serum CA-125 level. Cytogenetics and comparative genomic hybridization (CGH) analysis of his tumor identified a single extra copy number of chromosome 11 with few other changes noted.

KW - Cancer genetics

KW - Mesothelioma

KW - Rare tumors

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Clinical, histologic, and genetic features of mesothelioma in a 7-Year-old child

Abstract

Keywords

ASJC Scopus subject areas

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