Clinical, histologic, and genetic features of mesothelioma in a 7-Year-old child

Aaron Sugalski, Mary Davis, Latha Prasannan, Victor Saldivar, Jaclyn Y. Hung, Gail E. Tomlinson

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Malignant mesothelioma (MM) is a highly aggressive malignancy that is extremely rare in children. This case report documents a 7-year-old male without previous asbestos exposure with peritoneal MM that initially responded to chemotherapy with cisplatin and gemcitabine but ultimately metastasized to his chest. He was diagnosed with MM based on histology, extensive immunohistochemical analyses, and an elevated serum CA-125 level. Cytogenetics and comparative genomic hybridization (CGH) analysis of his tumor identified a single extra copy number of chromosome 11 with few other changes noted.

Original languageEnglish (US)
Pages (from-to)146-148
Number of pages3
JournalPediatric Blood and Cancer
Volume60
Issue number1
DOIs
StatePublished - Jan 2013

Keywords

  • Cancer genetics
  • Mesothelioma
  • Rare tumors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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