Clinical gallbladder disease in NIDDM subjects: Relationship to duration of diabetes and severity of glycemia

Steven M. Haffner, Andrew K. Diehl, Rodolfo Valdez, Braxton D. Mitchell, Helen P. Hazuda, Philip Morales, Michael P. Stern

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


OBJECTIVE - To examine the relationship between the prevalence of gallbladder disease and severity of glycemia among diabetic individuals and to provide insight into whether the diabetes-gallstone association is a causal one, because NIDDM patients have an increased prevalence of clinical gallbladder disease. RESEARCH DESIGN AND METHODS - We examined 462 diabetic individuals identified during the San Antonio Heart Study, a population-based survey of diabetes and cardiovascular disease in Mexican Americans and non-Hispanic whites. Diabetes was diagnosed according to National Diabetes Data Group criteria. RESULTS - The prevalence of self-reported gallbladder disease was 34.2% in diabetic women and 7.2% in diabetic men. Although duration of diabetes was positively related to the prevalence of gallbladder disease (P < 0.01), type of therapy was not associated, and fasting glucose concentration was inversely associated with gallbladder disease. CONCLUSIONS - Factors other than hyperglycemia may account for the increased prevalence of gallbladder disease in diabetic subjects.

Original languageEnglish (US)
Pages (from-to)1276-1284
Number of pages9
JournalDiabetes care
Issue number9
StatePublished - Sep 1993

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing


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