Clinical features of 31 patients with Ki-1 anaplastic large-cell lymphoma

John P. Greer, Marsha C. Kinney, Robert D. Collins, Kevin E. Salhany, Steven N. Wolff, John D. Hainsworth, John M. Flexner, Richard S. Stein

Research output: Contribution to journalArticle

182 Scopus citations

Abstract

Thirty-one patients were diagnosed by morphologic and immunophenotypic features as having primary Ki-1 anaplastic large-cell lymphoma (Ki-1 ALCL). The median age was 35 years (range, 4 months to 78 years); the male:female ratio was 18:13. B symptoms were observed in 13 patients. Peripheral adenopathy was present in 26 patients, while mediastinal adenopathy occurred in five. There was extranodal disease in 13 patients; the most common extranodal site was skin with seven affected. Seventeen patients had stage III/IV disease. Immunophenotypes were T cell in 24 patients and B cell in four patients; immunophenotype could not be determined in three patients. Cytogenetic abnormalities in chromosomes 2, 5, and 7 were detected in three patients. Although therapy was heterogeneous, the actuarial 2-year survival was 73%. Two-year disease-free survival was 39% for all patients; for stages I and II, it was 62% compared with 20% for stages III and IV (P = .001). Complete remission (CR) occurred in 21 of 23 patients receiving combination chemotherapy; however, nine relapses, including six of seven stage IV patients, occurred within 21 months of diagnosis. Preliminary observations suggest that Ki-1 ALCL may have a quiescent phase in the rare patient with only localized skin disease. However, the disease generally behaves as an intermediate- to high-grade lymphoma, and patients with Ki-1 ALCL should receive curative-intent combination chemotherapy.

Original languageEnglish (US)
Pages (from-to)539-547
Number of pages9
JournalJournal of Clinical Oncology
Volume9
Issue number4
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Greer, J. P., Kinney, M. C., Collins, R. D., Salhany, K. E., Wolff, S. N., Hainsworth, J. D., Flexner, J. M., & Stein, R. S. (1991). Clinical features of 31 patients with Ki-1 anaplastic large-cell lymphoma. Journal of Clinical Oncology, 9(4), 539-547. https://doi.org/10.1200/JCO.1991.9.4.539