Clinical feasibility study of combined optoacoustic and ultrasonic imaging modality providing coregistered functional and anatomical maps of breast tumors

Jason Zalev, Don Herzog, Bryan Clingman, Tom Miller, Kenneth Kist, N. Carol Dornbluth, B. Michelle McCorvey, Pamela Otto, Sergey Ermilov, Vyacheslav Nadvoretsky, Andre Conjusteau, Richard Su, Dmitri Tsyboulski, Alexander Oraevsky

Research output: Chapter in Book/Report/Conference proceedingConference contribution

13 Scopus citations

Abstract

Two-dimensional optoacoustic imaging with a hand-held probe operated in backward mode is being developed for diagnostic imaging of breast cancer to evaluate the feasibility of a dual-modality optoacoustic plus ultrasonic system that maps functional information of anatomical tissue structures with ultrasonic resolution. Tissue is illuminated at 757nm and 1064nm for optical contrast between hypoxic blood of breast carcinomas and normally oxygenated blood in benign masses. The system is optimized and calibrated in phantoms for a pilot clinical study of patients with breast masses suspected for malignancy. Capability of the non-invasive system to improve detection and diagnosis of breast tumors is discussed.

Original languageEnglish (US)
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2012
DOIs
StatePublished - Apr 9 2012
EventPhotons Plus Ultrasound: Imaging and Sensing 2012 - San Francisco, CA, United States
Duration: Jan 22 2012Jan 24 2012

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8223
ISSN (Print)1605-7422

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2012
CountryUnited States
CitySan Francisco, CA
Period1/22/121/24/12

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Keywords

  • Breast cancer diagnosis
  • In-vivo functional imaging
  • Optoacoustic

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Zalev, J., Herzog, D., Clingman, B., Miller, T., Kist, K., Dornbluth, N. C., McCorvey, B. M., Otto, P., Ermilov, S., Nadvoretsky, V., Conjusteau, A., Su, R., Tsyboulski, D., & Oraevsky, A. (2012). Clinical feasibility study of combined optoacoustic and ultrasonic imaging modality providing coregistered functional and anatomical maps of breast tumors. In Photons Plus Ultrasound: Imaging and Sensing 2012 [82230A] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8223). https://doi.org/10.1117/12.910968