Clinical differences in COPD patients with variable patterns of hypoxemia

For the Long-Term Oxygen Treatment Trial Research Group

Research output: Contribution to journalArticle

Abstract

Background: Chronic obstructive pulmonary disease (COPD) patients enrolled into the Long-term Oxygen Treatment Trial had hypoxemia at rest, hypoxemia on exertion, or hypoxemia both at rest and on exertion. We hypothesized that patients with different patterns of hypoxemia may have significant differences in clinical features. Methods: All patients had COPD and oxygen saturation measured by pulse oximetry (blood oxygenation [SpO2]) at rest and during the 6-minute walk test (6MWT). Hypoxemia at rest was defined as resting SpO2 between 89-93%. SpO2<90% for at least 10 seconds and ≥80% for at least 5 minutes during ambulation characterized hypoxemia on exertion. Severe exercise hypoxemia (<80% for >1 minute) was exclusionary. Results: Of 738 patients studied, 133 (18.0%) had mild-moderate hypoxemia at rest only, 319 (43.2%) had hypoxemia on exertion only, and 286 (38.8%) had hypoxemia at both rest and exertion. Patients with hypoxemia at rest only were more likely to be current smokers, had higher body mass index (BMI) and a higher incidence of self-reported diabetes. Patients with hypoxemia on exertion only were more severely obstructed compared to the other groups. General and disease-specific quality of life scores were similarly impaired in all groups. Quality of well-being scores were more impaired in those with hypoxemia at rest only. Conclusions: COPD patients with mild-moderate hypoxemia have distinct clinical characteristics based on the pattern of oxygen desaturation at rest and with exertion.

Original languageEnglish (US)
Pages (from-to)167-178
Number of pages12
JournalChronic Obstructive Pulmonary Diseases
Volume5
Issue number3
DOIs
StatePublished - Jan 1 2018

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Chronic Obstructive Pulmonary Disease
Oxygen
Hypoxia
Oximetry
Body Mass Index
Quality of Life

Keywords

  • Chronic obstructive pulmonary disease
  • COPD
  • Long-term oxygen treatment
  • Long-term Oxygen Treatment Trial
  • LOTT

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Clinical differences in COPD patients with variable patterns of hypoxemia. / For the Long-Term Oxygen Treatment Trial Research Group.

In: Chronic Obstructive Pulmonary Diseases, Vol. 5, No. 3, 01.01.2018, p. 167-178.

Research output: Contribution to journalArticle

For the Long-Term Oxygen Treatment Trial Research Group. / Clinical differences in COPD patients with variable patterns of hypoxemia. In: Chronic Obstructive Pulmonary Diseases. 2018 ; Vol. 5, No. 3. pp. 167-178.
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title = "Clinical differences in COPD patients with variable patterns of hypoxemia",
abstract = "Background: Chronic obstructive pulmonary disease (COPD) patients enrolled into the Long-term Oxygen Treatment Trial had hypoxemia at rest, hypoxemia on exertion, or hypoxemia both at rest and on exertion. We hypothesized that patients with different patterns of hypoxemia may have significant differences in clinical features. Methods: All patients had COPD and oxygen saturation measured by pulse oximetry (blood oxygenation [SpO2]) at rest and during the 6-minute walk test (6MWT). Hypoxemia at rest was defined as resting SpO2 between 89-93{\%}. SpO2<90{\%} for at least 10 seconds and ≥80{\%} for at least 5 minutes during ambulation characterized hypoxemia on exertion. Severe exercise hypoxemia (<80{\%} for >1 minute) was exclusionary. Results: Of 738 patients studied, 133 (18.0{\%}) had mild-moderate hypoxemia at rest only, 319 (43.2{\%}) had hypoxemia on exertion only, and 286 (38.8{\%}) had hypoxemia at both rest and exertion. Patients with hypoxemia at rest only were more likely to be current smokers, had higher body mass index (BMI) and a higher incidence of self-reported diabetes. Patients with hypoxemia on exertion only were more severely obstructed compared to the other groups. General and disease-specific quality of life scores were similarly impaired in all groups. Quality of well-being scores were more impaired in those with hypoxemia at rest only. Conclusions: COPD patients with mild-moderate hypoxemia have distinct clinical characteristics based on the pattern of oxygen desaturation at rest and with exertion.",
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author = "{For the Long-Term Oxygen Treatment Trial Research Group} and Narewski, {Erin R.} and Blackford, {Amanda L.} and Lammi, {Matthew R.} and Fuhlbrigge, {Anne L.} and Xavier Soler and Richard Albert and Criner, {Gerard J.} and Bailey, {William C.} and Ernestina Sampong and Karin Sloan and Ashley Wagner and Susan Anderson and Marilyn Moy and Osarenoma Okunbor and Stoller, {James K.} and Scott Marlow and Yvonne Meli and Richard Rice and Aboussouan, {Loutfi S.} and Robert Castele and Joseph Parambil and Sumita Khatri and Aman Pande and Joe Zein and Thomas Olbrych and Stephan Alkins and Christine Jocko and Franck Rahaghi and Jean Barton and Albert, {Richard K.} and Jennifer Underwood and Barry Make and Neil MacIntyre and John Davies and Thomas Stibolt and Richard Mularski and Allison Naleway and Sarah Vertrees and Richard Casaburi and Janos Porszasz and Peggy Walker and Renee Indelicato and Lennard Specht and Kathleen Ellstrom and Jamie Portillo and David Horak and Brian Tiep and Mary Barnett and Philip Diaz and Anzueto, {Antonio R}",
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T1 - Clinical differences in COPD patients with variable patterns of hypoxemia

AU - For the Long-Term Oxygen Treatment Trial Research Group

AU - Narewski, Erin R.

AU - Blackford, Amanda L.

AU - Lammi, Matthew R.

AU - Fuhlbrigge, Anne L.

AU - Soler, Xavier

AU - Albert, Richard

AU - Criner, Gerard J.

AU - Bailey, William C.

AU - Sampong, Ernestina

AU - Sloan, Karin

AU - Wagner, Ashley

AU - Anderson, Susan

AU - Moy, Marilyn

AU - Okunbor, Osarenoma

AU - Stoller, James K.

AU - Marlow, Scott

AU - Meli, Yvonne

AU - Rice, Richard

AU - Aboussouan, Loutfi S.

AU - Castele, Robert

AU - Parambil, Joseph

AU - Khatri, Sumita

AU - Pande, Aman

AU - Zein, Joe

AU - Olbrych, Thomas

AU - Alkins, Stephan

AU - Jocko, Christine

AU - Rahaghi, Franck

AU - Barton, Jean

AU - Albert, Richard K.

AU - Underwood, Jennifer

AU - Make, Barry

AU - MacIntyre, Neil

AU - Davies, John

AU - Stibolt, Thomas

AU - Mularski, Richard

AU - Naleway, Allison

AU - Vertrees, Sarah

AU - Casaburi, Richard

AU - Porszasz, Janos

AU - Walker, Peggy

AU - Indelicato, Renee

AU - Specht, Lennard

AU - Ellstrom, Kathleen

AU - Portillo, Jamie

AU - Horak, David

AU - Tiep, Brian

AU - Barnett, Mary

AU - Diaz, Philip

AU - Anzueto, Antonio R

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Chronic obstructive pulmonary disease (COPD) patients enrolled into the Long-term Oxygen Treatment Trial had hypoxemia at rest, hypoxemia on exertion, or hypoxemia both at rest and on exertion. We hypothesized that patients with different patterns of hypoxemia may have significant differences in clinical features. Methods: All patients had COPD and oxygen saturation measured by pulse oximetry (blood oxygenation [SpO2]) at rest and during the 6-minute walk test (6MWT). Hypoxemia at rest was defined as resting SpO2 between 89-93%. SpO2<90% for at least 10 seconds and ≥80% for at least 5 minutes during ambulation characterized hypoxemia on exertion. Severe exercise hypoxemia (<80% for >1 minute) was exclusionary. Results: Of 738 patients studied, 133 (18.0%) had mild-moderate hypoxemia at rest only, 319 (43.2%) had hypoxemia on exertion only, and 286 (38.8%) had hypoxemia at both rest and exertion. Patients with hypoxemia at rest only were more likely to be current smokers, had higher body mass index (BMI) and a higher incidence of self-reported diabetes. Patients with hypoxemia on exertion only were more severely obstructed compared to the other groups. General and disease-specific quality of life scores were similarly impaired in all groups. Quality of well-being scores were more impaired in those with hypoxemia at rest only. Conclusions: COPD patients with mild-moderate hypoxemia have distinct clinical characteristics based on the pattern of oxygen desaturation at rest and with exertion.

AB - Background: Chronic obstructive pulmonary disease (COPD) patients enrolled into the Long-term Oxygen Treatment Trial had hypoxemia at rest, hypoxemia on exertion, or hypoxemia both at rest and on exertion. We hypothesized that patients with different patterns of hypoxemia may have significant differences in clinical features. Methods: All patients had COPD and oxygen saturation measured by pulse oximetry (blood oxygenation [SpO2]) at rest and during the 6-minute walk test (6MWT). Hypoxemia at rest was defined as resting SpO2 between 89-93%. SpO2<90% for at least 10 seconds and ≥80% for at least 5 minutes during ambulation characterized hypoxemia on exertion. Severe exercise hypoxemia (<80% for >1 minute) was exclusionary. Results: Of 738 patients studied, 133 (18.0%) had mild-moderate hypoxemia at rest only, 319 (43.2%) had hypoxemia on exertion only, and 286 (38.8%) had hypoxemia at both rest and exertion. Patients with hypoxemia at rest only were more likely to be current smokers, had higher body mass index (BMI) and a higher incidence of self-reported diabetes. Patients with hypoxemia on exertion only were more severely obstructed compared to the other groups. General and disease-specific quality of life scores were similarly impaired in all groups. Quality of well-being scores were more impaired in those with hypoxemia at rest only. Conclusions: COPD patients with mild-moderate hypoxemia have distinct clinical characteristics based on the pattern of oxygen desaturation at rest and with exertion.

KW - Chronic obstructive pulmonary disease

KW - COPD

KW - Long-term oxygen treatment

KW - Long-term Oxygen Treatment Trial

KW - LOTT

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U2 - 10.15326/jcopdf.5.3.2017.0175

DO - 10.15326/jcopdf.5.3.2017.0175

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SP - 167

EP - 178

JO - Chronic Obstructive Pulmonary Diseases

JF - Chronic Obstructive Pulmonary Diseases

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