Clinical correlates of gallstone composition: Distinguishing pigment from cholesterol stones

A. K. Diehl, Wayne H Schwesinger, D. R. Holleman, J. B. Chapman, W. E. Kurtin

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Original languageEnglish
Pages (from-to)967-972
Number of pages6
JournalAmerican Journal of Gastroenterology
Volume90
Issue number6
StatePublished - 1995

Fingerprint

Gallstones
Cholesterol
Cholelithiasis
Fibrosis
Thiazides
Cholecystectomy
Oral Contraceptives
Teaching Hospitals
Alcohol Drinking
Ultrasonography
Spectrum Analysis
Diabetes Mellitus
Logistic Models
Interviews

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Diehl, A. K., Schwesinger, W. H., Holleman, D. R., Chapman, J. B., & Kurtin, W. E. (1995). Clinical correlates of gallstone composition: Distinguishing pigment from cholesterol stones. American Journal of Gastroenterology, 90(6), 967-972.

Clinical correlates of gallstone composition : Distinguishing pigment from cholesterol stones. / Diehl, A. K.; Schwesinger, Wayne H; Holleman, D. R.; Chapman, J. B.; Kurtin, W. E.

In: American Journal of Gastroenterology, Vol. 90, No. 6, 1995, p. 967-972.

Research output: Contribution to journalArticle

Diehl, AK, Schwesinger, WH, Holleman, DR, Chapman, JB & Kurtin, WE 1995, 'Clinical correlates of gallstone composition: Distinguishing pigment from cholesterol stones', American Journal of Gastroenterology, vol. 90, no. 6, pp. 967-972.
Diehl, A. K. ; Schwesinger, Wayne H ; Holleman, D. R. ; Chapman, J. B. ; Kurtin, W. E. / Clinical correlates of gallstone composition : Distinguishing pigment from cholesterol stones. In: American Journal of Gastroenterology. 1995 ; Vol. 90, No. 6. pp. 967-972.
@article{bf5d45417cff4e79a27a924b7e1d664c,
title = "Clinical correlates of gallstone composition: Distinguishing pigment from cholesterol stones",
abstract = "Objectives: The prevalence of cholelithiasis has been established in population-based surveys employing ultrasonography, and major risk factors have been identified. However, the clinical and epidemiological features that distinguish patients with pigment gallstones from those with cholesterol stones have received little attention. Methods: We prospectively surveyed 551 patients undergoing cholecystectomy for gallstones at two teaching hospitals. Clinical and epidemiological data were collected during patient interviews and by chart review. Gallstones were collected at surgery; physical measurements were recorded, and stone composition was determined by visual inspection and infrared spectroscopy. Results: Patients with pigment stones were older than patients with cholesterol stones (p < 0.00001). Almost all patients under age 40 yr old had cholesterol stones, but most patients over 70 bad pigment stones. Cirrhosis was strongly associated with pigment gallstones (p < 0.00001), although alcohol consumption was unrelated. Univariate analyses suggested associations of stone composition with male sex, diabetes mellitus, educational attainment, and use of thiazides or oral contraceptives, but these were not significant in a logistic regression that adjusted for age, cirrhosis, and other variables. Patients with pigment cholelithiasis had stones that were generally smaller in diameter and fewer in number than those with cholesterol stones. Conclusions: Compared to patients with cholesterol gallstones, those with pigment stones are older and more likely to have a diagnosis of cirrhosis. In addition, their stones are smaller in size and fewer in number than those from patients with cholesterol cholelithiasis.",
author = "Diehl, {A. K.} and Schwesinger, {Wayne H} and Holleman, {D. R.} and Chapman, {J. B.} and Kurtin, {W. E.}",
year = "1995",
language = "English",
volume = "90",
pages = "967--972",
journal = "American Journal of Gastroenterology",
issn = "0002-9270",
publisher = "Nature Publishing Group",
number = "6",

}

TY - JOUR

T1 - Clinical correlates of gallstone composition

T2 - Distinguishing pigment from cholesterol stones

AU - Diehl, A. K.

AU - Schwesinger, Wayne H

AU - Holleman, D. R.

AU - Chapman, J. B.

AU - Kurtin, W. E.

PY - 1995

Y1 - 1995

N2 - Objectives: The prevalence of cholelithiasis has been established in population-based surveys employing ultrasonography, and major risk factors have been identified. However, the clinical and epidemiological features that distinguish patients with pigment gallstones from those with cholesterol stones have received little attention. Methods: We prospectively surveyed 551 patients undergoing cholecystectomy for gallstones at two teaching hospitals. Clinical and epidemiological data were collected during patient interviews and by chart review. Gallstones were collected at surgery; physical measurements were recorded, and stone composition was determined by visual inspection and infrared spectroscopy. Results: Patients with pigment stones were older than patients with cholesterol stones (p < 0.00001). Almost all patients under age 40 yr old had cholesterol stones, but most patients over 70 bad pigment stones. Cirrhosis was strongly associated with pigment gallstones (p < 0.00001), although alcohol consumption was unrelated. Univariate analyses suggested associations of stone composition with male sex, diabetes mellitus, educational attainment, and use of thiazides or oral contraceptives, but these were not significant in a logistic regression that adjusted for age, cirrhosis, and other variables. Patients with pigment cholelithiasis had stones that were generally smaller in diameter and fewer in number than those with cholesterol stones. Conclusions: Compared to patients with cholesterol gallstones, those with pigment stones are older and more likely to have a diagnosis of cirrhosis. In addition, their stones are smaller in size and fewer in number than those from patients with cholesterol cholelithiasis.

AB - Objectives: The prevalence of cholelithiasis has been established in population-based surveys employing ultrasonography, and major risk factors have been identified. However, the clinical and epidemiological features that distinguish patients with pigment gallstones from those with cholesterol stones have received little attention. Methods: We prospectively surveyed 551 patients undergoing cholecystectomy for gallstones at two teaching hospitals. Clinical and epidemiological data were collected during patient interviews and by chart review. Gallstones were collected at surgery; physical measurements were recorded, and stone composition was determined by visual inspection and infrared spectroscopy. Results: Patients with pigment stones were older than patients with cholesterol stones (p < 0.00001). Almost all patients under age 40 yr old had cholesterol stones, but most patients over 70 bad pigment stones. Cirrhosis was strongly associated with pigment gallstones (p < 0.00001), although alcohol consumption was unrelated. Univariate analyses suggested associations of stone composition with male sex, diabetes mellitus, educational attainment, and use of thiazides or oral contraceptives, but these were not significant in a logistic regression that adjusted for age, cirrhosis, and other variables. Patients with pigment cholelithiasis had stones that were generally smaller in diameter and fewer in number than those with cholesterol stones. Conclusions: Compared to patients with cholesterol gallstones, those with pigment stones are older and more likely to have a diagnosis of cirrhosis. In addition, their stones are smaller in size and fewer in number than those from patients with cholesterol cholelithiasis.

UR - http://www.scopus.com/inward/record.url?scp=0029027662&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029027662&partnerID=8YFLogxK

M3 - Article

C2 - 7771432

AN - SCOPUS:0029027662

VL - 90

SP - 967

EP - 972

JO - American Journal of Gastroenterology

JF - American Journal of Gastroenterology

SN - 0002-9270

IS - 6

ER -