Clinical cellular cardiomyoplasty: Technical considerations

Fumin Zhang, Zhijian Yang, Yijiang Chen, Jianwei Qin, Tiebing Zhu, Di Xu, Zhaoqiang Xu, Qingbin Xu, Yi Qian, Wenzhu Ma, Lizhen Chen, Xiang Gao, Chuanfu Li, Tuanzhu Ha, Race L. Kao

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Three patients, all with a history of coronary heart disease, underwent coronary artery bypass grafting and implantation of autologous satellite cells. Satellite cells were isolated from muscle biopsies of the right vastus lateralis muscle after enzymatic treatment. While the heart was still under hypothermic cardioplegia, 4 mL of cell suspension divided into approximately 40 doses was injected into the ventricular wall of the ischemic area. Less than 5 minutes were required to complete the cell implantation. All patients survived the procedure, without obvious arrhythmia, had an uneventful recovery, and were discharged from the hospital. At 3 to 4 months follow-up examination, increased left ventricular ejection fraction, decreased left ventricular diastolic diameter, as well as improved ventricular wall thickness and perfusion at the satellite cell implantation sites were observed. Our experience indicated the safety and early benefit of cellular cardiomyoplasty using autologous satellite cells.

Original languageEnglish (US)
Pages (from-to)268-273
Number of pages6
JournalJournal of Cardiac Surgery
Volume18
Issue number3
DOIs
StatePublished - May 1 2003

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ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Zhang, F., Yang, Z., Chen, Y., Qin, J., Zhu, T., Xu, D., Xu, Z., Xu, Q., Qian, Y., Ma, W., Chen, L., Gao, X., Li, C., Ha, T., & Kao, R. L. (2003). Clinical cellular cardiomyoplasty: Technical considerations. Journal of Cardiac Surgery, 18(3), 268-273. https://doi.org/10.1046/j.1540-8191.2003.02043.x