Clinical applications of gene therapy in head and neck cancer

Michalis V. Karamouzis, Athanassios Argiris, Jennifer Rubin Grandis

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Despite advances in surgery, radiotherapy, and the incorporation of novel systemic agents into treatment, longterm outcomes of patients with head and neck cancer remain unsatisfactory. The growing understanding of head and neck cancer biology suggests that targeting molecular events governing carcinogenesis or tumor progression may provide novel therapeutic approaches for head and neck cancer. Squamous cell carcinoma of the head and neck (SCCRN) is characterized by locoregional spread and is clinically accessible, making it an attractive target for intratumoral gene therapy, a potentially efficacious experimental treatment. Systemic delivery of gene therapy may be also possible, albeit with several limitations. In this review we will discuss the rationale, delivery methods, and accumulated clinical data with cancer gene therapy in SCCHN.

Original languageEnglish (US)
Pages (from-to)446-457
Number of pages12
JournalCurrent Gene Therapy
Volume7
Issue number6
DOIs
StatePublished - Dec 1 2007
Externally publishedYes

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Keywords

  • Angiogenesis
  • Apoptosis
  • Clinical trials
  • Gene therapy
  • Head and neck cancer
  • Immune system
  • RNA
  • Vector
  • Virus

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Drug Discovery
  • Genetics(clinical)

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