Clinical angiographic regression of atherosclerosis after partial ileal bypass

Henry Buchwald, Richard B. Moore, Richard D. Rucker, Kurt Amplatz, Wilfredo R. Castaneda, Richard A. Francoz, Richard C. Pasternak, Richard L. Varco

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Clinical documentation of atherosclerotic plaque regression has been difficult to obtain. This is a report of a patient with severe and early atherosclerotic cardiovascular disease with regression of at least three major atherosclerotic lesions demonstrated by coronary arteriography 10 years after partial ileal bypass operation. The patient's total plasma cholesterol was reduced over these 10 years, ranging from 40% to 23%, from the preoperative level of 757 mg/dl. Sequential arteriograms were assessed independently by several arteriographers and blindly by the Arteriography Review Panel of the Program on Surgical Control of the Hyperlipidemias (POSCH). The readings were analyzed by 4 grading methods. Unanimously, marked regression was read in the proximal left circumflex artery (70% → 20%), middle segment of the right coronary artery (45% → 20%), and in the distal right coronary artery (80% → 50%). Thus, by any and all of the methods used, there was significant regression of arteriographically demonstrated atherosclerotic lesions.

Original languageEnglish (US)
Pages (from-to)117-128
Number of pages12
JournalAtherosclerosis
Volume46
Issue number1
DOIs
StatePublished - 1983
Externally publishedYes

Fingerprint

Atherosclerosis
Coronary Vessels
Angiography
Atherosclerotic Plaques
Hyperlipidemias
Documentation
Reading
Cardiovascular Diseases
Arteries
Cholesterol

Keywords

  • Atherosclerotic lesion regression - Coronary arteriography - Partial ileal bypass - Plasma cholesterol and cholesterol fractions - POSCH Arteriography Review Panel

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Buchwald, H., Moore, R. B., Rucker, R. D., Amplatz, K., Castaneda, W. R., Francoz, R. A., ... Varco, R. L. (1983). Clinical angiographic regression of atherosclerosis after partial ileal bypass. Atherosclerosis, 46(1), 117-128. https://doi.org/10.1016/0021-9150(83)90170-3

Clinical angiographic regression of atherosclerosis after partial ileal bypass. / Buchwald, Henry; Moore, Richard B.; Rucker, Richard D.; Amplatz, Kurt; Castaneda, Wilfredo R.; Francoz, Richard A.; Pasternak, Richard C.; Varco, Richard L.

In: Atherosclerosis, Vol. 46, No. 1, 1983, p. 117-128.

Research output: Contribution to journalArticle

Buchwald, H, Moore, RB, Rucker, RD, Amplatz, K, Castaneda, WR, Francoz, RA, Pasternak, RC & Varco, RL 1983, 'Clinical angiographic regression of atherosclerosis after partial ileal bypass', Atherosclerosis, vol. 46, no. 1, pp. 117-128. https://doi.org/10.1016/0021-9150(83)90170-3
Buchwald H, Moore RB, Rucker RD, Amplatz K, Castaneda WR, Francoz RA et al. Clinical angiographic regression of atherosclerosis after partial ileal bypass. Atherosclerosis. 1983;46(1):117-128. https://doi.org/10.1016/0021-9150(83)90170-3
Buchwald, Henry ; Moore, Richard B. ; Rucker, Richard D. ; Amplatz, Kurt ; Castaneda, Wilfredo R. ; Francoz, Richard A. ; Pasternak, Richard C. ; Varco, Richard L. / Clinical angiographic regression of atherosclerosis after partial ileal bypass. In: Atherosclerosis. 1983 ; Vol. 46, No. 1. pp. 117-128.
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AB - Clinical documentation of atherosclerotic plaque regression has been difficult to obtain. This is a report of a patient with severe and early atherosclerotic cardiovascular disease with regression of at least three major atherosclerotic lesions demonstrated by coronary arteriography 10 years after partial ileal bypass operation. The patient's total plasma cholesterol was reduced over these 10 years, ranging from 40% to 23%, from the preoperative level of 757 mg/dl. Sequential arteriograms were assessed independently by several arteriographers and blindly by the Arteriography Review Panel of the Program on Surgical Control of the Hyperlipidemias (POSCH). The readings were analyzed by 4 grading methods. Unanimously, marked regression was read in the proximal left circumflex artery (70% → 20%), middle segment of the right coronary artery (45% → 20%), and in the distal right coronary artery (80% → 50%). Thus, by any and all of the methods used, there was significant regression of arteriographically demonstrated atherosclerotic lesions.

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