Clinical and virological characterization of persistent human infection with simian foamy viruses

Roumiana S. Boneva, William M. Switzer, Thomas J. Spira, Vinod B. Bhullar, Vedapuri Shanmugam, Mian Er Cong, Lee Lam, Walid Heneine, Thomas M. Folks, Louisa E. Chapman

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Persons occupationally exposed to nonhuman primates (NHPs) can be persistently infected with simian foamy virus (SFV). The clinical significance and person-to-person transmissibility of zoonotic SFV infection is unclear. Seven SFV-infected men responded to annual structured interviews and provided whole blood, oral, and urogenital specimens for study. Wives were tested for SFV infection. Proviral DNA was consistently detected by PCR in PBMCs of infected men and inconsistently in oral or urogenital samples. SFV was infrequently cultured from their PBMCs and throat swabs. Despite this and a long period of intimate exposure (median 20 years), wives were SFV negative. Most participants reported nonspecific symptoms and diseases common to aging. However, one of two persons with mild thrombocytopenia had clinically asymptomatic nonprogressive, monoclonal natural killer cell lymphocytosis of unclear relationship to SFV. All participants worked with NHPs before 1988 using mucocutaneous protection inconsistently; 57% described percutaneous injuries involving the infecting NHP species. SFV likely transmits to humans through both percutaneous and mucocutaneous exposures to NHP body fluids. Limited follow-up has not identified SFV-associated illness and secondary transmission among humans.

Original languageEnglish (US)
Pages (from-to)1330-1337
Number of pages8
JournalAIDS Research and Human Retroviruses
Volume23
Issue number11
DOIs
StatePublished - Nov 1 2007
Externally publishedYes

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Simian foamy virus
Infection
Primates
Virus Diseases
Spouses
Lymphocytosis
Zoonoses
Body Fluids
Pharynx
Natural Killer Cells
Thrombocytopenia

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

Cite this

Boneva, R. S., Switzer, W. M., Spira, T. J., Bhullar, V. B., Shanmugam, V., Cong, M. E., ... Chapman, L. E. (2007). Clinical and virological characterization of persistent human infection with simian foamy viruses. AIDS Research and Human Retroviruses, 23(11), 1330-1337. https://doi.org/10.1089/aid.2007.0104

Clinical and virological characterization of persistent human infection with simian foamy viruses. / Boneva, Roumiana S.; Switzer, William M.; Spira, Thomas J.; Bhullar, Vinod B.; Shanmugam, Vedapuri; Cong, Mian Er; Lam, Lee; Heneine, Walid; Folks, Thomas M.; Chapman, Louisa E.

In: AIDS Research and Human Retroviruses, Vol. 23, No. 11, 01.11.2007, p. 1330-1337.

Research output: Contribution to journalArticle

Boneva, RS, Switzer, WM, Spira, TJ, Bhullar, VB, Shanmugam, V, Cong, ME, Lam, L, Heneine, W, Folks, TM & Chapman, LE 2007, 'Clinical and virological characterization of persistent human infection with simian foamy viruses', AIDS Research and Human Retroviruses, vol. 23, no. 11, pp. 1330-1337. https://doi.org/10.1089/aid.2007.0104
Boneva, Roumiana S. ; Switzer, William M. ; Spira, Thomas J. ; Bhullar, Vinod B. ; Shanmugam, Vedapuri ; Cong, Mian Er ; Lam, Lee ; Heneine, Walid ; Folks, Thomas M. ; Chapman, Louisa E. / Clinical and virological characterization of persistent human infection with simian foamy viruses. In: AIDS Research and Human Retroviruses. 2007 ; Vol. 23, No. 11. pp. 1330-1337.
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