TY - JOUR
T1 - Clinical and molecular correlates of the ASPECTS in the acute phase of stroke
AU - Mourão, Aline Mansueto
AU - Vicente, Laélia Cristina Caseiro
AU - Abreu, Mery Natali Silva
AU - Sant'Anna, Romeu Vale
AU - de Meira, Fidel Castro Alves
AU - Xavier, Rodrigo Menezes de Brito
AU - Tanure, Marco Túlio de Azevedo
AU - Vieira, Erica Leandro Marciano
AU - de Souza, Leonardo Cruz
AU - Miranda, de Aline Silva
AU - Rachid, Milene Alvarenga
AU - Teixeira, Antônio Lucio
N1 - Publisher Copyright:
© 2020 Associacao Arquivos de Neuro-Psiquiatria. All rights reserved.
PY - 2020/5
Y1 - 2020/5
N2 - Background: The Alberta Stroke Program Early CT Score (ASPECTS) scale was developed for monitoring early ischemic changes on CT, being associated with clinical outcomes. The ASPECTS can also associate with peripheral biomarkers that reflect the pathophysiological response of the brain to the ischemic stroke. Objective: To investigate the association between peripheral biomarkers with the Alberta Stroke Program Early CT Score (ASPECTS) in individuals after ischemic stroke. Methods: Patients over 18 years old with acute ischemic stroke were enrolled in this study. No patient was eligible for thrombolysis. The patients were submitted to non-contrast CT in the first 24 hours of admission, being the Alberta Stroke Program Early CT Score and clinical and molecular evaluations applied on the same day. The National Institutes of Health Stroke Scale (NIHSS), modified Rankin scale and the Mini-Mental State Examination for clinical evaluation were also applied to all subjects. Plasma levels of BDNF, VCAM-1, VEGF, IL-1β, sTNFRs and adiponectin were determined by ELISA. Results: Worse neurological impairment (NIHSS), cognitive (MEEM) and functional (Rankin) performance was observed in the group with changes in the NCTT. Patients with NCTT changes also exhibited higher levels of IL-1β and adiponectin. In the linear multivariate regression, an adjusted R coefficient of 0.515 was found, indicating adiponectin and NIHSS as independent predictors of ASPECTS. Conclusion: Plasma levels of adiponectin are associated with the ASPECTS scores.
AB - Background: The Alberta Stroke Program Early CT Score (ASPECTS) scale was developed for monitoring early ischemic changes on CT, being associated with clinical outcomes. The ASPECTS can also associate with peripheral biomarkers that reflect the pathophysiological response of the brain to the ischemic stroke. Objective: To investigate the association between peripheral biomarkers with the Alberta Stroke Program Early CT Score (ASPECTS) in individuals after ischemic stroke. Methods: Patients over 18 years old with acute ischemic stroke were enrolled in this study. No patient was eligible for thrombolysis. The patients were submitted to non-contrast CT in the first 24 hours of admission, being the Alberta Stroke Program Early CT Score and clinical and molecular evaluations applied on the same day. The National Institutes of Health Stroke Scale (NIHSS), modified Rankin scale and the Mini-Mental State Examination for clinical evaluation were also applied to all subjects. Plasma levels of BDNF, VCAM-1, VEGF, IL-1β, sTNFRs and adiponectin were determined by ELISA. Results: Worse neurological impairment (NIHSS), cognitive (MEEM) and functional (Rankin) performance was observed in the group with changes in the NCTT. Patients with NCTT changes also exhibited higher levels of IL-1β and adiponectin. In the linear multivariate regression, an adjusted R coefficient of 0.515 was found, indicating adiponectin and NIHSS as independent predictors of ASPECTS. Conclusion: Plasma levels of adiponectin are associated with the ASPECTS scores.
KW - Biomarkers
KW - Brain Ischemia
KW - Neurologic Examination
KW - Neurology
KW - Prognosis
UR - http://www.scopus.com/inward/record.url?scp=85085962351&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85085962351&partnerID=8YFLogxK
U2 - 10.1590/0004-282x20200001
DO - 10.1590/0004-282x20200001
M3 - Article
C2 - 32490969
AN - SCOPUS:85085962351
SN - 0004-282X
VL - 78
SP - 262
EP - 268
JO - Arquivos de neuro-psiquiatria
JF - Arquivos de neuro-psiquiatria
IS - 5
ER -