Clinical and molecular correlates of the ASPECTS in the acute phase of stroke

Aline Mansueto Mourão, Laélia Cristina Caseiro Vicente, Mery Natali Silva Abreu, Romeu Vale Sant'Anna, Fidel Castro Alves de Meira, Rodrigo Menezes de Brito Xavier, Marco Túlio de Azevedo Tanure, Erica Leandro Marciano Vieira, Leonardo Cruz de Souza, de Aline Silva Miranda, Milene Alvarenga Rachid, Antônio Lucio Teixeira

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background: The Alberta Stroke Program Early CT Score (ASPECTS) scale was developed for monitoring early ischemic changes on CT, being associated with clinical outcomes. The ASPECTS can also associate with peripheral biomarkers that reflect the pathophysiological response of the brain to the ischemic stroke. Objective: To investigate the association between peripheral biomarkers with the Alberta Stroke Program Early CT Score (ASPECTS) in individuals after ischemic stroke. Methods: Patients over 18 years old with acute ischemic stroke were enrolled in this study. No patient was eligible for thrombolysis. The patients were submitted to non-contrast CT in the first 24 hours of admission, being the Alberta Stroke Program Early CT Score and clinical and molecular evaluations applied on the same day. The National Institutes of Health Stroke Scale (NIHSS), modified Rankin scale and the Mini-Mental State Examination for clinical evaluation were also applied to all subjects. Plasma levels of BDNF, VCAM-1, VEGF, IL-1β, sTNFRs and adiponectin were determined by ELISA. Results: Worse neurological impairment (NIHSS), cognitive (MEEM) and functional (Rankin) performance was observed in the group with changes in the NCTT. Patients with NCTT changes also exhibited higher levels of IL-1β and adiponectin. In the linear multivariate regression, an adjusted R coefficient of 0.515 was found, indicating adiponectin and NIHSS as independent predictors of ASPECTS. Conclusion: Plasma levels of adiponectin are associated with the ASPECTS scores.

Original languageEnglish (US)
Pages (from-to)262-268
Number of pages7
JournalArquivos de neuro-psiquiatria
Issue number5
StatePublished - May 2020
Externally publishedYes


  • Biomarkers
  • Brain Ischemia
  • Neurologic Examination
  • Neurology
  • Prognosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry


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