Abstract
Background: Chronic bronchitis (CB) has been related to poor outcomes in Chronic Obstructive Pulmonary Disease (COPD). From a clinical standpoint, we have shown that subjects with CB in a group with moderate to severe airflow obstruction were younger, more likely to be current smokers, male, Caucasian, had worse health related quality of life, more dyspnea, and increased exacerbation history compared to those without CB. We sought to further refine our clinical characterization of chronic bronchitics in a larger cohort and analyze the CT correlates of CB in COPD subjects. We hypothesized that COPD patients with CB would have thicker airways and a greater history of smoking, acute bronchitis, allergic rhinitis, and occupational exposures compared to those without CB.Methods: We divided 2703 GOLD 1-4 subjects in the Genetic Epidemiology of COPD (COPDGene®) Study into two groups based on symptoms: chronic bronchitis (CB+, n = 663, 24.5%) and no chronic bronchitis (CB-, n = 2040, 75.5%). Subjects underwent extensive clinical characterization, and quantitative CT analysis to calculate mean wall area percent (WA%) of 6 segmental airways was performed using VIDA PW2 (http://www.vidadiagnostics.com). Square roots of the wall areas of bronchi with internal perimeters 10 mm and 15 mm (Pi10 and Pi15, respectively), % emphysema, %gas trapping, were calculated using 3D Slicer (http://www.slicer.org).Results: There were no differences in % emphysema (11.4 ± 12.0 vs. 12.0 ± 12.6%, p = 0.347) or % gas trapping (35.3 ± 21.2 vs. 36.3 ± 20.6%, p = 0.272) between groups. Mean segmental WA% (63.0 ± 3.2 vs. 62.0 ± 3.1%, p < 0.0001), Pi10 (3.72 ± 0.15 vs. 3.69 ± 0.14 mm, p < 0.0001), and Pi15 (5.24 ± 0.22 vs. 5.17 ± 0.20, p < 0.0001) were greater in the CB + group. Greater percentages of gastroesophageal reflux, allergic rhinitis, histories of asthma and acute bronchitis, exposures to dusts and occupational exposures, and current smokers were seen in the CB + group. In multivariate binomial logistic regression, male gender, Caucasian race, a lower FEV1%, allergic rhinitis, history of acute bronchitis, current smoking, and increased airway wall thickness increased odds for having CB.Conclusions: Histories of asthma, allergic rhinitis, acute bronchitis, current smoking, a lower FEV1%, Caucasian race, male gender, and increased airway wall thickness are associated with CB. These data provide clinical and radiologic correlations to the clinical phenotype of CB.
| Original language | English (US) |
|---|---|
| Article number | 52 |
| Journal | Respiratory research |
| Volume | 15 |
| Issue number | 1 |
| DOIs | |
| State | Published - Apr 27 2014 |
Keywords
- Airway thickening
- Asthma
- Chronic bronchitis
- Chronic obstructive pulmonary disease
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
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Clinical and computed tomographic predictors of chronic bronchitis in COPD : A cross sectional analysis of the COPDGene study. / Kim, Victor; Davey, Adam; Comellas, Alejandro P.; Han, Meilan K.; Washko, George; Martinez, Carlos H.; Lynch, David; Lee, Jin H.; Silverman, Edwin K.; Crapo, James D.; Make, Barry J.; Criner, Gerard J.; Farzadegan, Homayoon; Bragan, Samantha; Cayetano, Stacey; Curtis, Jeffrey; Kazerooni, Ella; Hanania, Nicola; Alapat, Philip; Bandi, Venkata; Guntupalli, Kalpalatha; Guy, Elizabeth; Mallampalli, Antara; Trinh, Charles; Atik, Mustafa; Al-Azzawi, Hasan; Willis, Marc; Pinero, Susan; Fahr, Linda; Nachiappan, Arun; Bray, Collin; Frigini, L. Alexander; Farinas, Carlos; Katz, David; Freytes, Jose; Marciel, Anne Marie; DeMeo, Dawn; Hersh, Craig; Jacobson, Francine; Hatabu, Hiroto; Clarke, Peter; Gill, Ritu; Hunsaker, Andetta; Trotman-Dickenson, Beatrice; Madan, Rachna; Barr, R. Graham; Thomashow, Byron; Austin, John; D'Souza, Belinda; MacIntyre, Neil; Washington, Lacey; McAdams, H. Page; Rosiello, Richard; Bresnahan, Timothy; Bradley, Joseph; Kuong, Sharon; Meller, Steven; Roland, Suzanne; McEvoy, Charlene; Tashjian, Joseph; Wise, Robert; Hansel, Nadia; Brown, Robert; Diette, Gregory; Horton, Karen; Casaburi, Richard; Porszasz, Janos; Fischer, Hans; Budoff, Matt; Rambod, Mehdi; Sharafkhaneh, Amir; Kamal, Hirani; Darvishi, Roham; Niewoehner, Dennis; Anderson, Quentin; Rice, Kathryn; Caine, Audrey; Foreman, Marilyn; Westney, Gloria; Berkowitz, Eugene; Bowler, Russell; Schroeder, Joyce; Hale, Valerie; Armstrong, John; Dyer, Debra; Chung, Jonathan; Cox, Christian; Marchetti, Nathaniel; Satti, Aditi; Mamary, A. James; Steiner, Robert; Dass, Chandra; Cone, Libby; Bailey, William; Dransfield, Mark; Wells, Michael; Bhatt, Surya; Nath, Hrudaya; Singh, Satinder; Ramsdell, Joe; Friedman, Paul; Cornellas, Alejandro; Newell, John; van Beek, Edwin J.R.; Martinez, Fernando; Wendt, Christine; Allen, Tadashi; Sciurba, Frank; Weissfeld, Joel; Fuhrman, Carl; Bon, Jessica; Hooper, Danielle; Anzueto, Antonio; Adams, Sandra; Orozco, Carlos; Ruiz, Mario; Mumbower, Amy; Kruger, Ariel; Restrepo, Carlos; Lane, Michael; Akhavan, Jaleh; Al Qaisi, Mustafa; Beaty, Terri; Black-Shinn, Jennifer; Bleecker, Eugene R.; Bowler, Russell P.; Bratschie, Stephanie; Castaldic, Peter J.; Cho, Michael; Cox, Christian W.; Coxson, Harvey O.; Croxton, Thomas; Crystal, Ronald G.; Curtis, Jeffrey L.; Cusick, Deanna; DeMeo, Dawn L.; Dy, Jennifer G.; Everett, Douglas; Foreman, Marilyn G.; Gan, Weiniu; Ginsburg, Shoshana; Hansel, Nadia N.; Hardin, Megan E.; Hersh, Craig P.; Hetmanski, Jacqueline; Hoffman, Eric A.; Hogg, James C.; Hokanson, John; Hokanson, John E.; Jensen, Robert; Jose Estepar, Raul San; Judy, Philip F.; Kinney, Gregory; Kluiber, Alex; Knowles, Ruthie; Laird, Nan; Lange, Christoph; Lantz, Rochelle; Lutz, Sharon M.; Mattheisen, Manuel; McDonaldc, Merry Lynn; McKenzie, Alexander; Melanson, Sandra; Newell, John D.; Parker, Margaret M.; Plant, Randel; Postow, Lisa; Prieto, Delia; Province, Michael A.; Regan, Elizabeth A.; Reilly, John J.; Rennard, Stephen I.; Rossc, James; Santorico, Stephanie; Schroeder, Joyce D.; Sieren, Jered; Sitek, Arkadiusz; Stepp, Lori; Stinson, Douglas; Sutherland, E. Rand; Thomas, Duncan C.; Walsh, John W.; Wan, Emily S.; Williams, Andre; Wilson, Carla; Zach, Jordan; Zhou, Jin; van Beek, Edwin.
In: Respiratory research, Vol. 15, No. 1, 52, 27.04.2014.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Clinical and computed tomographic predictors of chronic bronchitis in COPD
T2 - A cross sectional analysis of the COPDGene study
AU - Kim, Victor
AU - Davey, Adam
AU - Comellas, Alejandro P.
AU - Han, Meilan K.
AU - Washko, George
AU - Martinez, Carlos H.
AU - Lynch, David
AU - Lee, Jin H.
AU - Silverman, Edwin K.
AU - Crapo, James D.
AU - Make, Barry J.
AU - Criner, Gerard J.
AU - Farzadegan, Homayoon
AU - Bragan, Samantha
AU - Cayetano, Stacey
AU - Curtis, Jeffrey
AU - Kazerooni, Ella
AU - Hanania, Nicola
AU - Alapat, Philip
AU - Bandi, Venkata
AU - Guntupalli, Kalpalatha
AU - Guy, Elizabeth
AU - Mallampalli, Antara
AU - Trinh, Charles
AU - Atik, Mustafa
AU - Al-Azzawi, Hasan
AU - Willis, Marc
AU - Pinero, Susan
AU - Fahr, Linda
AU - Nachiappan, Arun
AU - Bray, Collin
AU - Frigini, L. Alexander
AU - Farinas, Carlos
AU - Katz, David
AU - Freytes, Jose
AU - Marciel, Anne Marie
AU - DeMeo, Dawn
AU - Hersh, Craig
AU - Jacobson, Francine
AU - Hatabu, Hiroto
AU - Clarke, Peter
AU - Gill, Ritu
AU - Hunsaker, Andetta
AU - Trotman-Dickenson, Beatrice
AU - Madan, Rachna
AU - Barr, R. Graham
AU - Thomashow, Byron
AU - Austin, John
AU - D'Souza, Belinda
AU - MacIntyre, Neil
AU - Washington, Lacey
AU - McAdams, H. Page
AU - Rosiello, Richard
AU - Bresnahan, Timothy
AU - Bradley, Joseph
AU - Kuong, Sharon
AU - Meller, Steven
AU - Roland, Suzanne
AU - McEvoy, Charlene
AU - Tashjian, Joseph
AU - Wise, Robert
AU - Hansel, Nadia
AU - Brown, Robert
AU - Diette, Gregory
AU - Horton, Karen
AU - Casaburi, Richard
AU - Porszasz, Janos
AU - Fischer, Hans
AU - Budoff, Matt
AU - Rambod, Mehdi
AU - Sharafkhaneh, Amir
AU - Kamal, Hirani
AU - Darvishi, Roham
AU - Niewoehner, Dennis
AU - Anderson, Quentin
AU - Rice, Kathryn
AU - Caine, Audrey
AU - Foreman, Marilyn
AU - Westney, Gloria
AU - Berkowitz, Eugene
AU - Bowler, Russell
AU - Schroeder, Joyce
AU - Hale, Valerie
AU - Armstrong, John
AU - Dyer, Debra
AU - Chung, Jonathan
AU - Cox, Christian
AU - Marchetti, Nathaniel
AU - Satti, Aditi
AU - Mamary, A. James
AU - Steiner, Robert
AU - Dass, Chandra
AU - Cone, Libby
AU - Bailey, William
AU - Dransfield, Mark
AU - Wells, Michael
AU - Bhatt, Surya
AU - Nath, Hrudaya
AU - Singh, Satinder
AU - Ramsdell, Joe
AU - Friedman, Paul
AU - Cornellas, Alejandro
AU - Newell, John
AU - van Beek, Edwin J.R.
AU - Martinez, Fernando
AU - Wendt, Christine
AU - Allen, Tadashi
AU - Sciurba, Frank
AU - Weissfeld, Joel
AU - Fuhrman, Carl
AU - Bon, Jessica
AU - Hooper, Danielle
AU - Anzueto, Antonio
AU - Adams, Sandra
AU - Orozco, Carlos
AU - Ruiz, Mario
AU - Mumbower, Amy
AU - Kruger, Ariel
AU - Restrepo, Carlos
AU - Lane, Michael
AU - Akhavan, Jaleh
AU - Al Qaisi, Mustafa
AU - Beaty, Terri
AU - Black-Shinn, Jennifer
AU - Bleecker, Eugene R.
AU - Bowler, Russell P.
AU - Bratschie, Stephanie
AU - Castaldic, Peter J.
AU - Cho, Michael
AU - Cox, Christian W.
AU - Coxson, Harvey O.
AU - Croxton, Thomas
AU - Crystal, Ronald G.
AU - Curtis, Jeffrey L.
AU - Cusick, Deanna
AU - DeMeo, Dawn L.
AU - Dy, Jennifer G.
AU - Everett, Douglas
AU - Foreman, Marilyn G.
AU - Gan, Weiniu
AU - Ginsburg, Shoshana
AU - Hansel, Nadia N.
AU - Hardin, Megan E.
AU - Hersh, Craig P.
AU - Hetmanski, Jacqueline
AU - Hoffman, Eric A.
AU - Hogg, James C.
AU - Hokanson, John
AU - Hokanson, John E.
AU - Jensen, Robert
AU - Jose Estepar, Raul San
AU - Judy, Philip F.
AU - Kinney, Gregory
AU - Kluiber, Alex
AU - Knowles, Ruthie
AU - Laird, Nan
AU - Lange, Christoph
AU - Lantz, Rochelle
AU - Lutz, Sharon M.
AU - Mattheisen, Manuel
AU - McDonaldc, Merry Lynn
AU - McKenzie, Alexander
AU - Melanson, Sandra
AU - Newell, John D.
AU - Parker, Margaret M.
AU - Plant, Randel
AU - Postow, Lisa
AU - Prieto, Delia
AU - Province, Michael A.
AU - Regan, Elizabeth A.
AU - Reilly, John J.
AU - Rennard, Stephen I.
AU - Rossc, James
AU - Santorico, Stephanie
AU - Schroeder, Joyce D.
AU - Sieren, Jered
AU - Sitek, Arkadiusz
AU - Stepp, Lori
AU - Stinson, Douglas
AU - Sutherland, E. Rand
AU - Thomas, Duncan C.
AU - Walsh, John W.
AU - Wan, Emily S.
AU - Williams, Andre
AU - Wilson, Carla
AU - Zach, Jordan
AU - Zhou, Jin
AU - van Beek, Edwin
N1 - Funding Information: This study was supported by the NHLBI R01 HL089856 and R01 HL08989. VK is supported by NHLBI K23HL094696-03. VK has participated in clinical trials sponsored by Boehringer Ingelheim, Glaxo-Smith-Kline, and Roche pharmaceuticals. AD, JC, and CHM report no conflicts. APC has been a consultant for VIDA diagnostics. Also, APC has participated in clinical trials sponsored by Boehringer Ingelheim, Glaxo-Smith-Kline, and Astra-Zeneca, and Forest. MKH has participated in advisory boards for Boehringer Ingelheim, Pfizer, GlaxoSmithKline, Genentech, Novartis, and Medimmune; participated on speaker’s bureaus for Boehringer Ingelheim, Pfizer, GlaxoSmithKline, Forest, Grifols therapeutics, and the National Association for Continuing Education, and WebMD; has consulted for Novartis, Ikaria and United Biosource Corporation; and has received royalties from UpToDate and ePocrates. GW has received grants from the NHLBI to perform quantitative image analysis and have been a paid consultant for MedImmune and Spiration, and his spouse is an employee of Merck Research Laboratories. Over the last three years, BJM has participated in advisory boards, speaker bureaus, consultations and multi-center clinical trials with funding from the National Heart Lung and Blood Institute, Abbott, Astellas, AstraZeneca, Boerhinger-Ingelheim, Coviden, Dey, Forest, GlaxoSmithKline, Merck, MedImmune, NABI, Novartis, Pfizer, Respironics, Sepracor, Sequal and Talecris. EKS received grant support from GlaxoSmithKline for studies of COPD genetics, and he received honoraria and consulting fees from AstraZeneca, Merck, and GlaxoSmithKline. DAL’s institution and laboratory receives research support from the National Heart Lung and Blood Institute, Siemens, Inc, Perceptive Imaging, Inc, and Centocor, Inc, Inc. Dr Lynch is a consultant to Perceptive Imaging, Inc, Boehringer Ingelheim, Inc, Genentech, Inc, Gilead, Inc, Veracyte, Inc and Intermune, Inc. GJC has served on Advisory Committees for Boehringer Ingelheim, CSA, Amirall and Holaira. All of these sums are less than $2,500. GJC has received research grants from: Boehringer Ingelheim, AstraZeneca, MedImmune, Pearl, Actelion, Glaxo-Smith-Kline, Forest, Aeris, Therapeutics, Pulmonx and PneumRx. All research grant monies are deposited and controlled by Temple University.
PY - 2014/4/27
Y1 - 2014/4/27
N2 - Background: Chronic bronchitis (CB) has been related to poor outcomes in Chronic Obstructive Pulmonary Disease (COPD). From a clinical standpoint, we have shown that subjects with CB in a group with moderate to severe airflow obstruction were younger, more likely to be current smokers, male, Caucasian, had worse health related quality of life, more dyspnea, and increased exacerbation history compared to those without CB. We sought to further refine our clinical characterization of chronic bronchitics in a larger cohort and analyze the CT correlates of CB in COPD subjects. We hypothesized that COPD patients with CB would have thicker airways and a greater history of smoking, acute bronchitis, allergic rhinitis, and occupational exposures compared to those without CB.Methods: We divided 2703 GOLD 1-4 subjects in the Genetic Epidemiology of COPD (COPDGene®) Study into two groups based on symptoms: chronic bronchitis (CB+, n = 663, 24.5%) and no chronic bronchitis (CB-, n = 2040, 75.5%). Subjects underwent extensive clinical characterization, and quantitative CT analysis to calculate mean wall area percent (WA%) of 6 segmental airways was performed using VIDA PW2 (http://www.vidadiagnostics.com). Square roots of the wall areas of bronchi with internal perimeters 10 mm and 15 mm (Pi10 and Pi15, respectively), % emphysema, %gas trapping, were calculated using 3D Slicer (http://www.slicer.org).Results: There were no differences in % emphysema (11.4 ± 12.0 vs. 12.0 ± 12.6%, p = 0.347) or % gas trapping (35.3 ± 21.2 vs. 36.3 ± 20.6%, p = 0.272) between groups. Mean segmental WA% (63.0 ± 3.2 vs. 62.0 ± 3.1%, p < 0.0001), Pi10 (3.72 ± 0.15 vs. 3.69 ± 0.14 mm, p < 0.0001), and Pi15 (5.24 ± 0.22 vs. 5.17 ± 0.20, p < 0.0001) were greater in the CB + group. Greater percentages of gastroesophageal reflux, allergic rhinitis, histories of asthma and acute bronchitis, exposures to dusts and occupational exposures, and current smokers were seen in the CB + group. In multivariate binomial logistic regression, male gender, Caucasian race, a lower FEV1%, allergic rhinitis, history of acute bronchitis, current smoking, and increased airway wall thickness increased odds for having CB.Conclusions: Histories of asthma, allergic rhinitis, acute bronchitis, current smoking, a lower FEV1%, Caucasian race, male gender, and increased airway wall thickness are associated with CB. These data provide clinical and radiologic correlations to the clinical phenotype of CB.
AB - Background: Chronic bronchitis (CB) has been related to poor outcomes in Chronic Obstructive Pulmonary Disease (COPD). From a clinical standpoint, we have shown that subjects with CB in a group with moderate to severe airflow obstruction were younger, more likely to be current smokers, male, Caucasian, had worse health related quality of life, more dyspnea, and increased exacerbation history compared to those without CB. We sought to further refine our clinical characterization of chronic bronchitics in a larger cohort and analyze the CT correlates of CB in COPD subjects. We hypothesized that COPD patients with CB would have thicker airways and a greater history of smoking, acute bronchitis, allergic rhinitis, and occupational exposures compared to those without CB.Methods: We divided 2703 GOLD 1-4 subjects in the Genetic Epidemiology of COPD (COPDGene®) Study into two groups based on symptoms: chronic bronchitis (CB+, n = 663, 24.5%) and no chronic bronchitis (CB-, n = 2040, 75.5%). Subjects underwent extensive clinical characterization, and quantitative CT analysis to calculate mean wall area percent (WA%) of 6 segmental airways was performed using VIDA PW2 (http://www.vidadiagnostics.com). Square roots of the wall areas of bronchi with internal perimeters 10 mm and 15 mm (Pi10 and Pi15, respectively), % emphysema, %gas trapping, were calculated using 3D Slicer (http://www.slicer.org).Results: There were no differences in % emphysema (11.4 ± 12.0 vs. 12.0 ± 12.6%, p = 0.347) or % gas trapping (35.3 ± 21.2 vs. 36.3 ± 20.6%, p = 0.272) between groups. Mean segmental WA% (63.0 ± 3.2 vs. 62.0 ± 3.1%, p < 0.0001), Pi10 (3.72 ± 0.15 vs. 3.69 ± 0.14 mm, p < 0.0001), and Pi15 (5.24 ± 0.22 vs. 5.17 ± 0.20, p < 0.0001) were greater in the CB + group. Greater percentages of gastroesophageal reflux, allergic rhinitis, histories of asthma and acute bronchitis, exposures to dusts and occupational exposures, and current smokers were seen in the CB + group. In multivariate binomial logistic regression, male gender, Caucasian race, a lower FEV1%, allergic rhinitis, history of acute bronchitis, current smoking, and increased airway wall thickness increased odds for having CB.Conclusions: Histories of asthma, allergic rhinitis, acute bronchitis, current smoking, a lower FEV1%, Caucasian race, male gender, and increased airway wall thickness are associated with CB. These data provide clinical and radiologic correlations to the clinical phenotype of CB.
KW - Airway thickening
KW - Asthma
KW - Chronic bronchitis
KW - Chronic obstructive pulmonary disease
UR - http://www.scopus.com/inward/record.url?scp=84903197851&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84903197851&partnerID=8YFLogxK
U2 - 10.1186/1465-9921-15-52
DO - 10.1186/1465-9921-15-52
M3 - Article
C2 - 24766722
AN - SCOPUS:84903197851
VL - 15
JO - Respiratory Research
JF - Respiratory Research
SN - 1465-9921
IS - 1
M1 - 52
ER -