Clearing the air: Uniquely engaging furin as an approach to cystic fibrosis therapy

Research output: Contribution to journalComment/debatepeer-review

Abstract

In this issue of Cell Chemical Biology, Douglas et al. describe a potent, specific, and cell-permeable furin inhibitor that interacts with a cryptic binding site to rescue hallmarks of cystic fibrosis in human ex vivo models. BOS-318 holds promise for development of therapeutics targeting an array of furin-dependent pathologies.

Original languageEnglish (US)
Pages (from-to)927-929
Number of pages3
JournalCell Chemical Biology
Volume29
Issue number6
DOIs
StatePublished - Jun 16 2022

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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