TY - JOUR
T1 - Clearing the air
T2 - Uniquely engaging furin as an approach to cystic fibrosis therapy
AU - Nayak, Digant
AU - Wasmuth, Elizabeth V.
AU - Olsen, Shaun K.
N1 - Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/6/16
Y1 - 2022/6/16
N2 - In this issue of Cell Chemical Biology, Douglas et al. describe a potent, specific, and cell-permeable furin inhibitor that interacts with a cryptic binding site to rescue hallmarks of cystic fibrosis in human ex vivo models. BOS-318 holds promise for development of therapeutics targeting an array of furin-dependent pathologies.
AB - In this issue of Cell Chemical Biology, Douglas et al. describe a potent, specific, and cell-permeable furin inhibitor that interacts with a cryptic binding site to rescue hallmarks of cystic fibrosis in human ex vivo models. BOS-318 holds promise for development of therapeutics targeting an array of furin-dependent pathologies.
UR - http://www.scopus.com/inward/record.url?scp=85132454254&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85132454254&partnerID=8YFLogxK
U2 - 10.1016/j.chembiol.2022.05.011
DO - 10.1016/j.chembiol.2022.05.011
M3 - Comment/debate
C2 - 35714591
AN - SCOPUS:85132454254
SN - 2451-9456
VL - 29
SP - 927
EP - 929
JO - Cell Chemical Biology
JF - Cell Chemical Biology
IS - 6
ER -