Class switching and Myc translocation: How does DNA break?

Paolo Casali; Hong Zan

doi:10.1038/ni1104-1101

Class switching and Myc translocation: How does DNA break?

Paolo Casali, Hong Zan

Research output: Contribution to journal › Comment/debate › peer-review

16 Scopus citations

Abstract

Chromosomal translocations involving immunoglobulin switch regions are commonly thought to arise from aberrant AID-induced DNA lesions. New data, however, suggest AID does not initiate such lesions, but acts subsequently in the B cell transformation process.

Original language	English (US)
Pages (from-to)	1101-1103
Number of pages	3
Journal	Nature Immunology
Volume	5
Issue number	11
DOIs	https://doi.org/10.1038/ni1104-1101
State	Published - Nov 2004
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1038/ni1104-1101

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title = "Class switching and Myc translocation: How does DNA break?",

abstract = "Chromosomal translocations involving immunoglobulin switch regions are commonly thought to arise from aberrant AID-induced DNA lesions. New data, however, suggest AID does not initiate such lesions, but acts subsequently in the B cell transformation process.",

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Class switching and Myc translocation: How does DNA break?

Abstract

ASJC Scopus subject areas

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