Class switching and Myc translocation: How does DNA break?

Research output: Contribution to journalComment/debatepeer-review

16 Scopus citations

Abstract

Chromosomal translocations involving immunoglobulin switch regions are commonly thought to arise from aberrant AID-induced DNA lesions. New data, however, suggest AID does not initiate such lesions, but acts subsequently in the B cell transformation process.

Original languageEnglish (US)
Pages (from-to)1101-1103
Number of pages3
JournalNature Immunology
Volume5
Issue number11
DOIs
StatePublished - Nov 2004
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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