Abstract
To clarify the site of the saluretic effect of chlorothiazide, these micropuncture studies examined the effect of chlorothiazide on chloride transport in the nephron. The effect of chlorothiazide on chloride transport was studied because chlorothiazide's effectiveness as a saluretic is largely due to its ability to enhance sodium chloride excretion; if only changes in sodium transport are examined, it would be then difficult to determine if sodium as bicarbonate or as chloride is affected, since chlorothiazide can inhibit carbonic anhydrase.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 401-407 |
| Number of pages | 7 |
| Journal | Journal of Clinical Investigation |
| Volume | 56 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1975 |
ASJC Scopus subject areas
- Medicine(all)
Fingerprint Dive into the research topics of 'Clarification of the site of action of chlorothiazide in the rat nephron'. Together they form a unique fingerprint.
Cite this
Kunau, R. T., Weller, D. R., & Webb, H. L. (1975). Clarification of the site of action of chlorothiazide in the rat nephron. Journal of Clinical Investigation, 56(2), 401-407. https://doi.org/10.1172/JCI108105