Cis-platinum ototoxicity in children

Thomas R. Pasic, Robert A. Dobie

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


Cis-platinum is an ototoxic antineoplastic drug. Evaluation of auditory thresholds in 33 children receiving cis-platinum shows that a threshold shift at 6 and 8 kHz is first measurable after a cumulative dose of 201 to 300 mg/m2. A 35- to 40-dB high-frequency threshold shift is evident after a cumulative cis-platinum dose of 301 to 400 mg/m2. Increasing cumulative doses of cis-platinum are associated with a greater degree of hearing loss. Receiver-operator characteristic curves were used to find a criterion value that effectively identified threshold shifts that were due to cis-platinum ototoxicity. A 15-dB or greater shift in the 6- and 8-kHz threshold average identifies a high true-positive (50%) and low false-positive (0%) rate of cis-platinum-induced hearing loss. Using this criterion, cis-platinum ototoxicity affected 77% of children who received cis-platinum (median cumulative dose 360 mg/m2).

Original languageEnglish (US)
Pages (from-to)985-991
Number of pages7
Issue number9
StatePublished - Sep 1991
Externally publishedYes

ASJC Scopus subject areas

  • Otorhinolaryngology


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