@article{5206a52ef76d424ca58defe50e724d45,
title = "Circulating thymic hormone levels in zinc deficiency",
abstract = "The effect of zinc deficiency (Zn-) on the circulating thymic hormone (FTS) levels in A/J mice was studied. After 3 weeks of feeding the mice a Zn- diet, FTS levels were markedly reduced and after 17 weeks, FTS was undetectable. By contrast, the zinc-supplemented (Zn+) group seemed to maintain FTS levels better than the normal diet group with aging. On the other hand, spleen spontaneous rosette-forming cells (sRFC) were studied for their azathioprine (AZ) sensitivity in A/J mice on different diets. The Zn- mice had fewer sRFC than did the normally fed or Zn+ mice. The role of zinc in controlling levels of FTS and thus thymic function is discussed.",
author = "T. Iwata and Incefy, {G. S.} and T. Tanaka and G. Fernandes and Menendez-Botet, {C. J.} and K. Pih and Good, {R. A.}",
note = "Funding Information: We are most grateful to Drs. M. Dardenne and J. F. Bach for their help in establishing the rosette inhibition assay in our laboratory. Special thanks are due to Ms. Carry Tsao and Ms. Waleeratana Buthrasup for excellent technical assistance. This study was supported by USPHS Grants CA-08748, CA-19267, CA-17404, CA-24476, AI-11843, RR-05534, NS-11457, and AG-00541, J. M. Foundation, the Special Projects Committee of Memorial Sloan-Kettering Cancer Center, the Fund for Advanced Study of Cancer, the Richard Molin Memorial Foundation, the Ortho Pharmaceutical Corporation, and the Earl M. Coleman Laboratory.",
year = "1979",
month = sep,
day = "15",
doi = "10.1016/0008-8749(79)90318-6",
language = "English (US)",
volume = "47",
pages = "100--105",
journal = "Cellular Immunology",
issn = "0008-8749",
publisher = "Academic Press Inc.",
number = "1",
}