@article{10898336c9074791b41046b855a59bdf,
title = "Circulating sex hormones in relation to anthropometric, sociodemographic and behavioural factors in an international dataset of 12,300 men",
abstract = "Introduction Sex hormones have been implicated in the etiology of a number of diseases. To better understand disease etiology and the mechanisms of disease-risk factor associations, this analysis aimed to investigate the associations of anthropometric, sociodemographic and behavioural factors with a range of circulating sex hormones and sex hormone-binding globulin. Methods Statistical analyses of individual participant data from 12,330 male controls aged 25–85 years from 25 studies involved in the Endogenous Hormones Nutritional Biomarkers and Prostate Cancer Collaborative Group. Analysis of variance was used to estimate geometric means adjusted for study and relevant covariates. Results Older age was associated with higher concentrations of sex hormone-binding globulin and dihydrotestosterone and lower concentrations of dehydroepiandrosterone sulfate, free testosterone, androstenedione, androstanediol glucuronide and free estradiol. Higher body mass index was associated with higher concentrations of free estradiol, androstanediol glucuronide, estradiol and estrone and lower concentrations of dihydrotestosterone, testosterone, sex hormone-binding globulin, free testosterone, androstenedione and dehydroepiandrosterone sulfate. Taller height was associated with lower concentrations of androstenedione, testosterone, free testosterone and sex hormone-binding globulin and higher concentrations of androstanediol glucuronide. Current smoking was associated with higher concentrations of androstenedione, sex hormone-binding globulin and testosterone. Alcohol consumption was associated with higher concentrations of dehydroepiandrosterone sulfate, androstenedione and androstanediol glucuronide. East Asians had lower concentrations of androstanediol glucuronide and African Americans had higher concentrations of estrogens. Education and marital status were modestly associated with a small number of hormones. Conclusion Circulating sex hormones in men are strongly associated with age and body mass index, and to a lesser extent with smoking status and alcohol consumption.",
author = "Watts, {Eleanor L.} and Appleby, {Paul N.} and Demetrius Albanes and Amanda Black and Chan, {June M.} and Chu Chen and Cirillo, {Piera M.} and Cohn, {Barbara A.} and Cook, {Michael B.} and Donovan, {Jenny L.} and Luigi Ferrucci and Garland, {Cedric F.} and Giles, {Graham G.} and Goodman, {Phyllis J.} and Habel, {Laurel A.} and Haiman, {Christopher A.} and Holly, {Jeff M.P.} and Hoover, {Robert N.} and Rudolf Kaaks and Paul Knekt and Kolonel, {Laurence N.} and Tatsuhiko Kubo and {Le Marchand}, Lo{\"i}c and Tapio Luostarinen and MacInnis, {Robert J.} and M{\"a}enp{\"a}{\"a}, {Hanna O.} and Satu M{\"a}nnist{\"o} and Metter, {E. Jeffrey} and Milne, {Roger L.} and Nomura, {Abraham M.Y.} and Oliver, {Steven E.} and Parsons, {J. Kellogg} and Peeters, {Petra H.} and Platz, {Elizabeth A.} and Elio Riboli and Fulvio Ricceri and Sabina Rinaldi and Harri Rissanen and Norie Sawada and Schaefer, {Catherine A.} and Schenk, {Jeannette M.} and Stanczyk, {Frank Z.} and Meir Stampfer and P{\"a}r Stattin and Stenman, {Ulf H{\aa}kan} and Anne Tj{\o}nneland and Antonia Trichopoulou and Thompson, {Ian M.} and Shoichiro Tsugane and Lars Vatten and Whittemore, {Alice S.} and Ziegler, {Regina G.} and Allen, {Naomi E.} and Key, {Timothy J.} and Travis, {Ruth C.}",
note = "Funding Information: Funding:Centralizedpooling,checkinganddata analysiswassupportedbyCancerResearchUK grantsC8221/A19170andC8221/A20986(https:// www.cancerresearchuk.org/).Detailsoffundingfor theoriginalstudiesareintherelevantpublications (seeSubjectsandmethodssectionforindividual studydetails).Theseinclude:EuniceKennedy ShriverNationalInstituteofChildHealthand Development,NationalInstitutesofHealthand DepartmentofHealthandHumanServices,grant number:HHSN275201100020C;California DepartmentofPublicHealthaspartofthe statewidecancerreportingprogrammandatedby CaliforniaHealthandSafetyCodeSection103885; theNationalCancerInstitute{\textquoteright}sSurveillance, EpidemiologyandEndResultsProgramawarded totheCancerPreventionInstituteofCalifornia, grantnumber:HHSN261201000140C;theNational CancerInstitute{\textquoteright}sSurveillance,Epidemiologyand EndResultsProgramawardedtotheUniversityof SouthernCalifornia,HHSN261201000035C; NationalCancerInstitute{\textquoteright}sSurveillance, EpidemiologyandEndResultsProgramawarded tothePublicHealthInstitute;theCentersfor DiseaseControlandPrevention{\textquoteright}sNationalProgram ofCancerRegistries,grantnumber: HHSN261201000034C;theCaliforniaDepartment ofPublicHealth,grantnumber:U58DP003862-01; theCancerResearchFund,underInteragency Agreement#97-12013(UniversityofCalifornia contract#98-00924V)withtheDepartmentof HealthServices,CancerResearchProgram,UM1 CA182883;theNationalCancerInstitute,National InstitutesofHealth/NationalCancerInstitute(grant numbersCA167552,CA055075,CA133891, CA141298,CA09001,CA131945,CA34944, CA40360,CA097193),NationalInstitutesofHealth/ NationalHeart,LungandBloodInstitute(grant numbersHL26490,HL34595)andtheHellenic HealthFoundation.Thefundershadnorolein studydesign,datacollectionandanalysis,decision topublish,orpreparationofthemanuscript.",
year = "2017",
month = dec,
doi = "10.1371/journal.pone.0187741",
language = "English (US)",
volume = "12",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "12",
}