Circulating miRNA associated with posttraumatic stress disorder in a cohort of military combat veterans

Christiana G. Martin, Hyungsuk Kim, Sijung Yun, Whitney Livingston, Joseph Fetta, Vincent Mysliwiec, Tristin Baxter, Jessica M. Gill

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Posttraumatic stress disorder (PTSD) affects many returning combat veterans, but underlying biological mechanisms remain unclear. In order to compare circulating micro RNA (miRNA) of combat veterans with and without PTSD, peripheral blood from 24 subjects was collected following deployment, and isolated miRNA was sequenced. PTSD was associated with 8 differentially expressed miRNA. Pathway analysis shows that PTSD is related to the axon guidance and Wnt signaling pathways, which work together to support neuronal development through regulation of growth cones. PTSD is associated with miRNAs that regulate biological functions including neuronal activities, suggesting that they play a role in PTSD symptomatology.

Original languageEnglish (US)
Pages (from-to)261-265
Number of pages5
JournalPsychiatry Research
Volume251
DOIs
StatePublished - May 1 2017
Externally publishedYes

Keywords

  • Biomarker
  • Micro RNA
  • PTSD

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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