Circulating MicroRNAs and Life Expectancy Among Identical Twins

Shenghui Wu, Taek Kyun Kim, Xiaogang Wu, Kelsey Scherler, David Baxter, Kai Wang, Ruth E. Krasnow, Terry Reed, Jun Dai

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Human life expectancy is influenced not only by longevity assurance mechanisms and disease susceptibility loci but also by the environment, gene–environment interactions, and chance. MicroRNAs (miRNAs) are a class of small noncoding RNAs closely related to genes. Circulating miRNAs have been shown as promising noninvasive biomarkers in the development of many pathophysiological conditions. However, the concentration of miRNA in the circulation may also be affected by environmental factors. We used a next-generation sequencing platform to assess the association of circulating miRNA with life expectancy, for which deaths are due to all causes independent of genes. In addition, we showed that miRNAs are present in 41-year archived plasma samples, which may be useful for both life expectancy and all-cause mortality risk assessment. Plasma miRNAs from nine identical male twins were profiled using next-generation sequencing. The average absolute difference in the minimum life expectancy was 9.68 years. Intraclass correlation coefficients were above 0.4 for 50% of miRNAs. Comparing deceased twins with their alive co-twin brothers, the concentrations were increased for 34 but decreased for 30 miRNAs. Identical twins discordant in life expectancy were dissimilar in the majority of miRNAs, suggesting that environmental factors are pivotal in miRNAs related to life expectancy.

Original languageEnglish (US)
Pages (from-to)247-256
Number of pages10
JournalAnnals of Human Genetics
Volume80
Issue number5
DOIs
StatePublished - Sep 1 2016

Keywords

  • Next-generation sequencing
  • all-cause mortality
  • life expectancy
  • microRNAs
  • twin

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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