Circulating levels of brain-derived neurotrophic factor: Correlation with mood, cognition and motor function

Antonio Lucio Teixeira, Izabela Guimarães Barbosa, Breno Satler Diniz, Arthur Kummer

Research output: Contribution to journalReview articlepeer-review

137 Scopus citations

Abstract

Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophin in the CNS, where it plays several pivotal roles in synaptic plasticity and neuronal survival. As a consequence, BDNF has become a key target in the physiopathology of several neurological and psychiatric diseases. Recent studies have consistently reported altered levels of BDNF in the circulation (i.e., serum or plasma) of patients with major depression, bipolar disorder, Alzheimers disease, Huntingtons disease and Parkinsons disease. Correlations between serum BDNF levels and affective, cognitive and motor symptoms have also been described. BDNF appears to be an unspecific biomarker of neuropsychiatric disorders characterized by neurodegenerative changes.

Original languageEnglish (US)
Pages (from-to)871-887
Number of pages17
JournalBiomarkers in Medicine
Volume4
Issue number6
DOIs
StatePublished - Dec 2010
Externally publishedYes

Keywords

  • Alzheimer's disease
  • amyotrophic lateral sclerosis
  • bipolar disorder
  • brain-derived neurotrophic factor
  • depression
  • Huntington's disease
  • Parkinson's disease
  • plasma
  • serum

ASJC Scopus subject areas

  • Drug Discovery
  • Clinical Biochemistry
  • Biochemistry, medical

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