TY - JOUR
T1 - Circulating levels of adipokines are altered in patients with temporal lobe epilepsy
AU - Toscano, Eliana Cristina de Brito
AU - Lessa, João Marcelo Korcsik
AU - Gonçalves, Ana Paula
AU - Rocha, Natalia Pessoa
AU - Giannetti, Alexandre Varella
AU - de Oliveira, Guilherme Nogueira
AU - Rachid, Milene Alvarenga
AU - Vieira, Érica Leandro Marciano
AU - Teixeira, Antônio Lúcio
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2019/1
Y1 - 2019/1
N2 - Objective: A persistent low-grade inflammatory state has been described in patients with temporal lobe epilepsy (TLE) in the interictal period. Adipokines are cytokines produced by the adipose tissue that can influence inflammatory response. The purpose of this study was to evaluate the plasma levels of adipokines in patients with TLE in comparison with controls. In addition, we sought to investigate whether the levels of adipokines were associated with clinical parameters in TLE. Methods: Forty patients with TLE and 40 controls were enrolled in this study. All participants were subjected to clinical assessment that included the Mini International Neuropsychiatric Interview (MINI) and the Hamilton Depression Rating Scale (HAM-D). Peripheral blood was drawn, and plasma levels of adipokines (adiponectin, leptin, and resistin) were measured by enzyme-linked immunoassay (ELISA). Results: People with TLE presented higher leptin and lower adiponectin and resistin levels in comparison with controls. The levels of these adipokines correlated negatively with illness length but not with other clinical parameters. In a binary logistic regression model, higher leptin and lower adiponectin levels remained as significant predictors of TLE diagnosis. Conclusions: These results corroborate the view that TLE is a multisystemic condition associated with low-grade inflammation.
AB - Objective: A persistent low-grade inflammatory state has been described in patients with temporal lobe epilepsy (TLE) in the interictal period. Adipokines are cytokines produced by the adipose tissue that can influence inflammatory response. The purpose of this study was to evaluate the plasma levels of adipokines in patients with TLE in comparison with controls. In addition, we sought to investigate whether the levels of adipokines were associated with clinical parameters in TLE. Methods: Forty patients with TLE and 40 controls were enrolled in this study. All participants were subjected to clinical assessment that included the Mini International Neuropsychiatric Interview (MINI) and the Hamilton Depression Rating Scale (HAM-D). Peripheral blood was drawn, and plasma levels of adipokines (adiponectin, leptin, and resistin) were measured by enzyme-linked immunoassay (ELISA). Results: People with TLE presented higher leptin and lower adiponectin and resistin levels in comparison with controls. The levels of these adipokines correlated negatively with illness length but not with other clinical parameters. In a binary logistic regression model, higher leptin and lower adiponectin levels remained as significant predictors of TLE diagnosis. Conclusions: These results corroborate the view that TLE is a multisystemic condition associated with low-grade inflammation.
KW - Adipokines
KW - Depression
KW - Inflammation
KW - Temporal lobe epilepsy
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U2 - 10.1016/j.yebeh.2018.11.023
DO - 10.1016/j.yebeh.2018.11.023
M3 - Article
C2 - 30530136
AN - SCOPUS:85057722617
SN - 1525-5050
VL - 90
SP - 137
EP - 141
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
ER -