Circulating levels of adipokines are altered in patients with temporal lobe epilepsy

Eliana Cristina de Brito Toscano, João Marcelo Korcsik Lessa, Ana Paula Gonçalves, Natalia Pessoa Rocha, Alexandre Varella Giannetti, Guilherme Nogueira de Oliveira, Milene Alvarenga Rachid, Érica Leandro Marciano Vieira, Antônio Lúcio Teixeira

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Objective: A persistent low-grade inflammatory state has been described in patients with temporal lobe epilepsy (TLE) in the interictal period. Adipokines are cytokines produced by the adipose tissue that can influence inflammatory response. The purpose of this study was to evaluate the plasma levels of adipokines in patients with TLE in comparison with controls. In addition, we sought to investigate whether the levels of adipokines were associated with clinical parameters in TLE. Methods: Forty patients with TLE and 40 controls were enrolled in this study. All participants were subjected to clinical assessment that included the Mini International Neuropsychiatric Interview (MINI) and the Hamilton Depression Rating Scale (HAM-D). Peripheral blood was drawn, and plasma levels of adipokines (adiponectin, leptin, and resistin) were measured by enzyme-linked immunoassay (ELISA). Results: People with TLE presented higher leptin and lower adiponectin and resistin levels in comparison with controls. The levels of these adipokines correlated negatively with illness length but not with other clinical parameters. In a binary logistic regression model, higher leptin and lower adiponectin levels remained as significant predictors of TLE diagnosis. Conclusions: These results corroborate the view that TLE is a multisystemic condition associated with low-grade inflammation.

Original languageEnglish (US)
Pages (from-to)137-141
Number of pages5
JournalEpilepsy and Behavior
StatePublished - Jan 2019
Externally publishedYes


  • Adipokines
  • Depression
  • Inflammation
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience


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