Circulating iga immune complexes in aids

Marilyn M. Lightfoote, Thomas M. Folks, Robert Redfield, Jonathan Gold, Kenneth W. Sell

    Research output: Contribution to journalArticlepeer-review

    26 Scopus citations

    Abstract

    Circulating immune complexes were isolated from the serum of patients with AIDS, as well as patients with other acute and chronic viral diseases. Analysis of these immune complexes by methods of flow cytometry and by radioimmune (Raji cell) assay revealed a prevalence of IgA complexes in the serum of AIDS patients and a prevalence of IgG complexes in the serum of patients with other viral diseases. Raji cells bind immune complexes via Fc and complement (C,) receptors and may detect IgA immune complexes more efficiently than a Clq assay since IgA has no affinity for Clq.

    Original languageEnglish (US)
    Pages (from-to)341-345
    Number of pages5
    JournalImmunological Investigations
    Volume14
    Issue number4
    DOIs
    StatePublished - Jan 1 1985

    ASJC Scopus subject areas

    • Immunology

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