Circadian rhythm of type II thyroxine-5'-deiodinase activity in the pineal gland: Controlling factors

R. J. Reiter, J. M. Guerrero, C. Santana, M. Puig-Domingo

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The presence of deiodinase activity in the mammalian pineal was noted 2 years ago. Since then, a marked rhythm in the activity has been described with the nighttime increase being mediated by the release of NE from sympathetic nerve ending which subsequently acts primarily on β-adrenergic receptors with cAMP serving as the intracellular second messenger. The functional significance of this marked 24 hour rhythm remains unknown.

Original languageEnglish (US)
Pages (from-to)95-98
Number of pages4
JournalAnnual Review of Chronopharmacology
Volume5
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Pharmacology

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