The presence of deiodinase activity in the mammalian pineal was noted 2 years ago. Since then, a marked rhythm in the activity has been described with the nighttime increase being mediated by the release of NE from sympathetic nerve ending which subsequently acts primarily on β-adrenergic receptors with cAMP serving as the intracellular second messenger. The functional significance of this marked 24 hour rhythm remains unknown.
|Original language||English (US)|
|Number of pages||4|
|Journal||Annual Review of Chronopharmacology|
|State||Published - Jan 1 1988|
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