TY - JOUR
T1 - Circadian rhythm in intraocular pressure
T2 - A rabbit model
AU - Rowland, J. M.
AU - Potter, D. E.
AU - Reiter, R. J.
N1 - Funding Information:
AKNOWLEDGEMENTS This research was supported by grants EY05403 (JMR) and EY02156 (DEP) from the National Eye Institute (NIH). Dr. Roland Menzel, Department of Physics, Texas Tech University, kindly provided the data on spectral intensity of lights used in the environmental chamber.
PY - 1981
Y1 - 1981
N2 - An animal model for study of the clrcadian rhythm in intraocular pressure (IOP) was developed using carefully maintained environmental lighting conditions. Highly predictable, precipitous increases and decreases in IOP of somewhat more than 10 mm Hg were found to be closely correlated with the onset of darkness and light, respectively. The daily spontaneous variations in IOP, once entrained, were maintained in constant darkness, but were eliminated by constant light, as is similarly seen in many mammalian systems. This model provides a novel means of investigating circadian IOP oscillation, which has been shown to be especially amplified in primary open angle glaucoma (POAG). This new rabbit model may also warrant consideration for use in screening ocular antihypertensive drugs since it could obviate the gross physiological manipulations and concomitant side effects inherent in the popular methods of inducing ocular hypertension in animal models.
AB - An animal model for study of the clrcadian rhythm in intraocular pressure (IOP) was developed using carefully maintained environmental lighting conditions. Highly predictable, precipitous increases and decreases in IOP of somewhat more than 10 mm Hg were found to be closely correlated with the onset of darkness and light, respectively. The daily spontaneous variations in IOP, once entrained, were maintained in constant darkness, but were eliminated by constant light, as is similarly seen in many mammalian systems. This model provides a novel means of investigating circadian IOP oscillation, which has been shown to be especially amplified in primary open angle glaucoma (POAG). This new rabbit model may also warrant consideration for use in screening ocular antihypertensive drugs since it could obviate the gross physiological manipulations and concomitant side effects inherent in the popular methods of inducing ocular hypertension in animal models.
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U2 - 10.3109/02713688109001822
DO - 10.3109/02713688109001822
M3 - Article
C2 - 7297102
AN - SCOPUS:0019796068
SN - 0271-3683
VL - 1
SP - 169
EP - 173
JO - Current Eye Research
JF - Current Eye Research
IS - 3
ER -