Circadian dependent chronoimmunological responses of T, B and natural killer cells

G. Fernandes, F. Halberg, R. A. Good

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Recent progress in immunology reveals both in man and mouse a complex interacting lymphoid cell network that exercises a variety of immune functions. Neurohumoral and endocrinological influences are involved in the control of both development and function of these cell populations. Thus immunity is in as dramatic way a function of interactions of these three of the body's major network. Variation in many immune responses are clearly influenced by circadian rhythm. For example, plaque forming cell responses to sheep red blood cells show a striking circadian periodicity which relates to the circadian stage at which antigen is injected. This phenomenon is concordant with much evidence that immunological responses are controlled by factors governing circadian physiology. Proliferative responses of lymphocytes of both mice and men to the phytomitogen PHA differ in circadian stage from the time when maximum responses to antigens are encountered. Natural killer cell functions of mice, rats, and men show clear evidence of circadian periodicity which may relate to the existence of a circadian periodicity of plasma cortisol levels. These cell-mediated functional activities may underly circadian resistance to tumor cells and possible circadian variability of responses to cancer therapy. Thus the possibility of using chrono-biologic synchronization to optimize these immunologic responses in vivo must be considered.

Original languageEnglish (US)
Pages (from-to)164-170
Number of pages7
Issue number4
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Immunology and Allergy


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