Cingulate function in depression: A potential predictor of treatment response

Helen S. Mayberg, Stephen K. Brannan, Roderick K. Mahurin, Paul A. Jerabek, Jerold S. Brickman, Janet L. Tekell, J. Arturo Silva, Scott McGinnis, Thomas G. Glass, Charles C. Martin, Peter T. Fox

Research output: Contribution to journalArticlepeer-review

928 Scopus citations


The relationship between pretreatment regional cerebral glucose metabolism and eventual antidepressant drug response was measured using positron emission tomography (PET) in hospitalized patients with unipolar depression. Rostral anterior cingulate metabolism uniquely differentiated eventual treatment responders from non-responders. Hypometabolism characterized non-responders when compared with controls, in contrast to responders who were hypermetabolic. Metabolism in no other region discriminated the two groups, nor did associated demographic, clinical or behavioral measures, including motor speed, cognitive performance, depression severity or illness chronicity. Cingulate hypermetabolism may represent an important adaptive response to depression and failure of this response may underlie poor outcome. A critical role for rostral cingulate area 24a/b in the limbic-cortical network involved in abnormal mood states is proposed.

Original languageEnglish (US)
Pages (from-to)1057-1061
Number of pages5
Issue number4
StatePublished - 1997


  • Cingulate
  • Depression
  • Limbic
  • Metabolism
  • PET
  • Prognosis

ASJC Scopus subject areas

  • Neuroscience(all)


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