Cingulate function in depression: A potential predictor of treatment response

Helen S. Mayberg; Stephen K. Brannan; Roderick K. Mahurin; Paul A. Jerabek; Jerold S. Brickman; Janet L. Tekell; J. Arturo Silva; Scott McGinnis; Thomas G. Glass; Charles C. Martin; Peter T. Fox

doi:10.1097/00001756-199703030-00048

Cingulate function in depression: A potential predictor of treatment response

Helen S. Mayberg, Stephen K. Brannan, Roderick K. Mahurin, Paul A. Jerabek, Jerold S. Brickman, Janet L. Tekell, J. Arturo Silva, Scott McGinnis, Thomas G. Glass, Charles C. Martin, Peter T. Fox

Research Imaging Institute

Research output: Contribution to journal › Article › peer-review

963 Scopus citations

Abstract

The relationship between pretreatment regional cerebral glucose metabolism and eventual antidepressant drug response was measured using positron emission tomography (PET) in hospitalized patients with unipolar depression. Rostral anterior cingulate metabolism uniquely differentiated eventual treatment responders from non-responders. Hypometabolism characterized non-responders when compared with controls, in contrast to responders who were hypermetabolic. Metabolism in no other region discriminated the two groups, nor did associated demographic, clinical or behavioral measures, including motor speed, cognitive performance, depression severity or illness chronicity. Cingulate hypermetabolism may represent an important adaptive response to depression and failure of this response may underlie poor outcome. A critical role for rostral cingulate area 24a/b in the limbic-cortical network involved in abnormal mood states is proposed.

Original language	English (US)
Pages (from-to)	1057-1061
Number of pages	5
Journal	NeuroReport
Volume	8
Issue number	4
DOIs	https://doi.org/10.1097/00001756-199703030-00048
State	Published - 1997

Keywords

Cingulate
Depression
Limbic
Metabolism
PET
Prognosis

ASJC Scopus subject areas

General Neuroscience

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10.1097/00001756-199703030-00048

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title = "Cingulate function in depression: A potential predictor of treatment response",

abstract = "The relationship between pretreatment regional cerebral glucose metabolism and eventual antidepressant drug response was measured using positron emission tomography (PET) in hospitalized patients with unipolar depression. Rostral anterior cingulate metabolism uniquely differentiated eventual treatment responders from non-responders. Hypometabolism characterized non-responders when compared with controls, in contrast to responders who were hypermetabolic. Metabolism in no other region discriminated the two groups, nor did associated demographic, clinical or behavioral measures, including motor speed, cognitive performance, depression severity or illness chronicity. Cingulate hypermetabolism may represent an important adaptive response to depression and failure of this response may underlie poor outcome. A critical role for rostral cingulate area 24a/b in the limbic-cortical network involved in abnormal mood states is proposed.",

keywords = "Cingulate, Depression, Limbic, Metabolism, PET, Prognosis",

author = "Mayberg, {Helen S.} and Brannan, {Stephen K.} and Mahurin, {Roderick K.} and Jerabek, {Paul A.} and Brickman, {Jerold S.} and Tekell, {Janet L.} and Silva, {J. Arturo} and Scott McGinnis and Glass, {Thomas G.} and Martin, {Charles C.} and Fox, {Peter T.}",

year = "1997",

doi = "10.1097/00001756-199703030-00048",

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AU - Brannan, Stephen K.

AU - Mahurin, Roderick K.

AU - Jerabek, Paul A.

AU - Brickman, Jerold S.

AU - Tekell, Janet L.

AU - Silva, J. Arturo

AU - McGinnis, Scott

AU - Glass, Thomas G.

AU - Martin, Charles C.

AU - Fox, Peter T.

PY - 1997

Y1 - 1997

N2 - The relationship between pretreatment regional cerebral glucose metabolism and eventual antidepressant drug response was measured using positron emission tomography (PET) in hospitalized patients with unipolar depression. Rostral anterior cingulate metabolism uniquely differentiated eventual treatment responders from non-responders. Hypometabolism characterized non-responders when compared with controls, in contrast to responders who were hypermetabolic. Metabolism in no other region discriminated the two groups, nor did associated demographic, clinical or behavioral measures, including motor speed, cognitive performance, depression severity or illness chronicity. Cingulate hypermetabolism may represent an important adaptive response to depression and failure of this response may underlie poor outcome. A critical role for rostral cingulate area 24a/b in the limbic-cortical network involved in abnormal mood states is proposed.

AB - The relationship between pretreatment regional cerebral glucose metabolism and eventual antidepressant drug response was measured using positron emission tomography (PET) in hospitalized patients with unipolar depression. Rostral anterior cingulate metabolism uniquely differentiated eventual treatment responders from non-responders. Hypometabolism characterized non-responders when compared with controls, in contrast to responders who were hypermetabolic. Metabolism in no other region discriminated the two groups, nor did associated demographic, clinical or behavioral measures, including motor speed, cognitive performance, depression severity or illness chronicity. Cingulate hypermetabolism may represent an important adaptive response to depression and failure of this response may underlie poor outcome. A critical role for rostral cingulate area 24a/b in the limbic-cortical network involved in abnormal mood states is proposed.

KW - Cingulate

KW - Depression

KW - Limbic

KW - Metabolism

KW - PET

KW - Prognosis

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Cingulate function in depression: A potential predictor of treatment response

Abstract

Keywords

ASJC Scopus subject areas

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