Cimetidine spares the glucuronidation of lorazepam and oxazepam

Rashmi V. Patwardhan, Garland W. Yarborough, Paul V. Desmond, Raymond F. Johnson, Steven Schenker, K. V. Speeg

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101 Scopus citations

Abstract

Lorazepam (Ativan) disposition and elimination were studied in 8 normal subjects before and after 1 wk of cimetidine therapy, 300 mg taken orally four times a day. In 4 of these 8 normal subjects the disposition and elimination of oxazepam (Serax) were also studied before and after similar treatment with cimetidine. Cimetidine did not alter the elimination of either lorazepam or oxazepam. Since both drugs are eliminated exclusively after conjugation as glucuronide, this study demonstrates a relative sparing of this pathway of biotransformation of drugs in subjects receiving cimetidine.

Original languageEnglish (US)
Pages (from-to)912-916
Number of pages5
JournalGastroenterology
Volume79
Issue number5
Publication statusPublished - Jan 1 1980

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ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Patwardhan, R. V., Yarborough, G. W., Desmond, P. V., Johnson, R. F., Schenker, S., & Speeg, K. V. (1980). Cimetidine spares the glucuronidation of lorazepam and oxazepam. Gastroenterology, 79(5), 912-916.