Cimetidine protects against stress-induced gastric injury augmented by mucosal barrier breakers

Barry A. Levine, Kenneth R. Sirinek, Basil A. Pruitt

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

An experimental rat model utilizing cold-restraint stress was employed to test the ability of an H2-receptor antagonist, cimetidine, to control gastric mucosal injury associated with stress augmented by the gastric mucosal barrier breakers, aspirin and taurocholate. Both aspirin and taurocholate, when combined with stress, caused a significant increase in gastric mucosal injury over that seen in animals receiving either stress alone or only gastric mucosal barrier breakers without stress. Pretreatment with cimetidine caused a significant reduction in gastric mucosal injury in stressed animals receiving gastric mucosal barrier breakers. This reduction was to the level of lesions seen in nonstressed animals.

Original languageEnglish (US)
Pages (from-to)328-331
Number of pages4
JournalThe American Journal of Surgery
Volume137
Issue number3
DOIs
StatePublished - Mar 1979

ASJC Scopus subject areas

  • Surgery

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