Cimetidine protects against stress-induced gastric injury augmented by mucosal barrier breakers

Barry A. Levine, Kenneth R Sirinek, Basil A Pruitt

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

An experimental rat model utilizing cold-restraint stress was employed to test the ability of an H2-receptor antagonist, cimetidine, to control gastric mucosal injury associated with stress augmented by the gastric mucosal barrier breakers, aspirin and taurocholate. Both aspirin and taurocholate, when combined with stress, caused a significant increase in gastric mucosal injury over that seen in animals receiving either stress alone or only gastric mucosal barrier breakers without stress. Pretreatment with cimetidine caused a significant reduction in gastric mucosal injury in stressed animals receiving gastric mucosal barrier breakers. This reduction was to the level of lesions seen in nonstressed animals.

Original languageEnglish (US)
Pages (from-to)328-331
Number of pages4
JournalThe American Journal of Surgery
Volume137
Issue number3
DOIs
StatePublished - 1979
Externally publishedYes

Fingerprint

Cimetidine
Stomach
Wounds and Injuries
Taurocholic Acid
Aspirin
Histamine H2 Receptors
Theoretical Models

ASJC Scopus subject areas

  • Surgery

Cite this

Cimetidine protects against stress-induced gastric injury augmented by mucosal barrier breakers. / Levine, Barry A.; Sirinek, Kenneth R; Pruitt, Basil A.

In: The American Journal of Surgery, Vol. 137, No. 3, 1979, p. 328-331.

Research output: Contribution to journalArticle

@article{d3cbb6a318bd40f78373b0ef100331d4,
title = "Cimetidine protects against stress-induced gastric injury augmented by mucosal barrier breakers",
abstract = "An experimental rat model utilizing cold-restraint stress was employed to test the ability of an H2-receptor antagonist, cimetidine, to control gastric mucosal injury associated with stress augmented by the gastric mucosal barrier breakers, aspirin and taurocholate. Both aspirin and taurocholate, when combined with stress, caused a significant increase in gastric mucosal injury over that seen in animals receiving either stress alone or only gastric mucosal barrier breakers without stress. Pretreatment with cimetidine caused a significant reduction in gastric mucosal injury in stressed animals receiving gastric mucosal barrier breakers. This reduction was to the level of lesions seen in nonstressed animals.",
author = "Levine, {Barry A.} and Sirinek, {Kenneth R} and Pruitt, {Basil A}",
year = "1979",
doi = "10.1016/0002-9610(79)90060-6",
language = "English (US)",
volume = "137",
pages = "328--331",
journal = "American Journal of Surgery",
issn = "0002-9610",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Cimetidine protects against stress-induced gastric injury augmented by mucosal barrier breakers

AU - Levine, Barry A.

AU - Sirinek, Kenneth R

AU - Pruitt, Basil A

PY - 1979

Y1 - 1979

N2 - An experimental rat model utilizing cold-restraint stress was employed to test the ability of an H2-receptor antagonist, cimetidine, to control gastric mucosal injury associated with stress augmented by the gastric mucosal barrier breakers, aspirin and taurocholate. Both aspirin and taurocholate, when combined with stress, caused a significant increase in gastric mucosal injury over that seen in animals receiving either stress alone or only gastric mucosal barrier breakers without stress. Pretreatment with cimetidine caused a significant reduction in gastric mucosal injury in stressed animals receiving gastric mucosal barrier breakers. This reduction was to the level of lesions seen in nonstressed animals.

AB - An experimental rat model utilizing cold-restraint stress was employed to test the ability of an H2-receptor antagonist, cimetidine, to control gastric mucosal injury associated with stress augmented by the gastric mucosal barrier breakers, aspirin and taurocholate. Both aspirin and taurocholate, when combined with stress, caused a significant increase in gastric mucosal injury over that seen in animals receiving either stress alone or only gastric mucosal barrier breakers without stress. Pretreatment with cimetidine caused a significant reduction in gastric mucosal injury in stressed animals receiving gastric mucosal barrier breakers. This reduction was to the level of lesions seen in nonstressed animals.

UR - http://www.scopus.com/inward/record.url?scp=0018768661&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018768661&partnerID=8YFLogxK

U2 - 10.1016/0002-9610(79)90060-6

DO - 10.1016/0002-9610(79)90060-6

M3 - Article

C2 - 434324

AN - SCOPUS:0018768661

VL - 137

SP - 328

EP - 331

JO - American Journal of Surgery

JF - American Journal of Surgery

SN - 0002-9610

IS - 3

ER -