TY - JOUR
T1 - Cimetidine inhibits renal procainamide clearance
AU - Christian, Charles D.
AU - Meredith, Christopher G.
AU - Speeg, K. V.
PY - 1984/8
Y1 - 1984/8
N2 - Procainamide and cimetidine are eliminated in large part by the kidneys. Both are secreted by an active transport mechanism in the proximal tubule and each inhibits secretion of the other in the isolated, perfused rabbit tubule. In this study in man, cimetidine inhibited renal clearance of oral procainamide by 36%. This was associated with a 28% decrease in the ratio of systemic clearance of procainamide to bioavailability, an 18% decrease in the elimination rate constant, and a 24% prolongation of elimination t 1 2. These results suggest that cimetidine increases plasma t 1 2 and decreases systemic clearance of procainamide in part by inhibiting its active secretion by the kidneys.
AB - Procainamide and cimetidine are eliminated in large part by the kidneys. Both are secreted by an active transport mechanism in the proximal tubule and each inhibits secretion of the other in the isolated, perfused rabbit tubule. In this study in man, cimetidine inhibited renal clearance of oral procainamide by 36%. This was associated with a 28% decrease in the ratio of systemic clearance of procainamide to bioavailability, an 18% decrease in the elimination rate constant, and a 24% prolongation of elimination t 1 2. These results suggest that cimetidine increases plasma t 1 2 and decreases systemic clearance of procainamide in part by inhibiting its active secretion by the kidneys.
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U2 - 10.1038/clpt.1984.166
DO - 10.1038/clpt.1984.166
M3 - Article
C2 - 6204803
AN - SCOPUS:0021238889
VL - 36
SP - 221
EP - 227
JO - Clinical Pharmacology and Therapeutics
JF - Clinical Pharmacology and Therapeutics
SN - 0009-9236
IS - 2
ER -