Cimetidine impairs elimination of chlordiazepoxide (librium) in man

P. V. Desmond, R. V. Patwardhan, S. Schenker, K. V. Speeg

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Abstract

We have studied chlordiazepoxide (Librium) disposition and elimination in eight normal subjects before and after 1 week of cimetidine therapy, 300 mg orally four times a day. Cimetidine strikingly impaired the clearance of chlordiazepoxide from plasma, and this was, at least in part, due to decreased demethylation of the drug to N-desmethylchlordiazepoxide. Since the volume of distribution of chlordiazepoxide was not altered by cimetidine, the elimination half-life of chlordiazepoxide was also significantly prolonged by cimetidine therapy.

Original languageEnglish (US)
Pages (from-to)266-268
Number of pages3
JournalAnnals of internal medicine
Volume93
Issue number2
DOIs
Publication statusPublished - Jan 1 1980

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ASJC Scopus subject areas

  • Internal Medicine

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