Ciliary blood flow and aqueous humor production

J. W. Kiel, M. Hollingsworth, R. Rao, M. Chen, H. A. Reitsamer

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations


Aqueous humor production is a metabolically active process sustained by the delivery of oxygen and nutrients and removal of metabolic waste by the ciliary circulation. This article describes our investigations into the relationship between ciliary blood flow and aqueous humor production. The results presented indicate that there is a dynamic relationship between ciliary blood flow and aqueous humor production, with production being blood flow independent above a critical level of perfusion, and blood flow dependent below it. The results also show that the plateau portion of the relationship shifts up or down depending on the level of secretory stimulation or inhibition, and that oxygen is one critical factor provided by ciliary blood flow. Also presented is a theoretical model of ocular hydrodynamics incorporating these new findings.

Original languageEnglish (US)
Pages (from-to)1-17
Number of pages17
JournalProgress in Retinal and Eye Research
Issue number1
StatePublished - Jan 2011


  • Aqueous humor dynamics
  • Aqueous humor production
  • Ciliary blood flow
  • Intraocular pressure

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems


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