CIDE proteins in human health and disease

Mark Slayton, Abhishek Gupta, Bijinu Balakrishnan, Vishwajeet Puri

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations

Abstract

Cell death-Inducing DNA Fragmentation Factor Alpha (DFFA)-like Effector (CIDE) proteins have emerged as lipid droplet-associated proteins that regulate fat metabolism. There are three members in the CIDE protein family—CIDEA, CIDEB, and CIDEC (also known as fat-specific protein 27 (FSP27)). CIDEA and FSP27 are primarily expressed in adipose tissue, while CIDEB is expressed in the liver. Originally, based upon their homology with DNA fragmentation factors, these proteins were identified as apoptotic proteins. However, recent studies have changed the perception of these proteins, redefining them as regulators of lipid droplet dynamics and fat metabolism, which contribute to a healthy metabolic phenotype in humans. Despite various studies in humans and gene-targeting studies in mice, the physiological roles of CIDE proteins remains elusive. This review will summarize the known physiological role and metabolic pathways regulated by the CIDE proteins in human health and disease.

Original languageEnglish (US)
Article number238
JournalCells
Volume8
Issue number3
DOIs
StatePublished - Mar 2019
Externally publishedYes

Keywords

  • Adipose
  • CIDEA
  • CIDEB
  • FSP27
  • Fat metabolism
  • Lipid droplets
  • Liver

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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