Chronology of neurological manifestations of prenatally diagnosed open neural tube defects

K. D. Ramin, C. Raffel, R. J. Breckle, P. L. Ogburn, J. D. Friedman, P. S. Ramsey

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Objective: To evaluate the incidence and chronology of sonographic markers of neurological compromise in prenatally diagnosed neural tube defects. Methods: We reviewed our ultrasound database from 1988 to 1999 to identify all cases of prenatally diagnosed neural tube defects. All patients received an initial detailed targeted ultrasound evaluation with subsequent evaluations every 4-6 weeks. Cases involving multiple congenital anomalies, aneuploidy, or inadequate follow-up were excluded. Specific ultrasound markers assessed included the presence of ventriculomegaly (> 10 mm) and clubfoot. Results: Forty-seven cases of neural tube defects were identified over the study interval. After exclusions, 42 cases were available for evaluation. The overall incidence of ventriculomegaly and clubfoot in the study cohort was 86% and 38%, respectively. In the 33 patients with initial ultrasound examination performed at < 24 weeks' gestation, 76% (25/33) had evidence of ventriculomegaly and 30% (10/33) and clubfoot. Only 9% (1/11) of the patients managed expectantly developed evidence of ventriculomegaly and 3/11 (27%) developed clubfoot from the time of the initial ultrasound examination to delivery. Conclusions: Ultrasound markers of neurological compromise are early and frequent findings associated with fetal neural tube defects. Development of ventriculomegaly is an uncommon occurrence later in gestation, while the risk for developing clubfoot appears to increase as gestation progresses.

Original languageEnglish (US)
Pages (from-to)89-92
Number of pages4
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume11
Issue number2
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

Keywords

  • Neural tube defects
  • Prenatal diagnosis
  • Prognosis
  • Spina bifida
  • Ultrasound

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Chronology of neurological manifestations of prenatally diagnosed open neural tube defects'. Together they form a unique fingerprint.

Cite this