Chronological studies of peripheral motor nerve conduction in 'lethargic' mice

J. M. Herring, H. C. Dung, J. H.K. Yoo, J. Yu

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Motor nerve conduction studies were carried out in the tail nerve of 'lethargic' mice and normal littermates at monthly intervals from one month to 10 month of age. The motor nerve conduction velocity (MNCV) evoked muscle action potential (EMAP) amplitude and distal motor latency (DML) data were compared statistically and theoretical maturation curves were developed by computer. Statistical analysis compared data for 'lethargic' and normal mice in the same age group, and the values at each month were compared with those at the 10th month which were assumed to represent adult values. A highly significant difference between 'lathargic' and normal mice was found in MNCV and DML at two months of age and after and at one one of age and after in EMAP amplitudes. MNCV and DML reached adult values at 4 months of age in both 'lethargics' and controls. Normal animals required 5 months to reach adult values of MNCV, whereas 'lethargics' required only three months. The computerized theoretical maturation curves agree with the statistical analysis, and suggest that there may be a basic difference in the maturation process of EMAP and MNCV in the first month or two of age.

Original languageEnglish (US)
Pages (from-to)121-134
Number of pages14
JournalElectromyography and Clinical Neurophysiology
Issue number2-3
StatePublished - 1981

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Physiology (medical)


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