Pineal melatonin production is highly cyclic and depends on alternating periods of light and darkness. Peak melatonin synthesis occurs during the dark phase of the light: dark cycle. Interruption of the sympathetic nerve supply to the pineal gland, exposure of the animals to continuous light, or the administration of a beta-adenergic antagonist obliterates the daily rise in pineal melatonin levels. At least in hamsters, circulating gonadal steroids seem to have minimal influence on the circadian rhythm in melatonin production.
|Original language||English (US)|
|Number of pages||11|
|Journal||Progress in clinical and biological research|
|Publication status||Published - Jan 1 1981|
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