Chronic n-methyl-d-aspartate administration prevents melatonin-associated changes in cell differentiation in the harderian glands of Male hamsters

Ana M. Coto-Montes, Maria J. Rodriguez-Colunga, Armando Menendez-Pelaez, Pat Hoover, Mary K. Vaughan, Russel J Reiter

Research output: Contribution to journalArticle

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Abstract

The daily administration of 25 μg of melatonin for 10 weeks resulted in an increase in the percentage of Type II cells in the Harderian glands of male Syrian hamsters. Harderian glands of melatonin injected animals consisted of 65-70% Type II cells while control animals which were injected with saline had 40% Type II secretory cells. The daily administration of 3 mg of the glutamate receptor agonist N-methyl-D-aspartate (NMDA) prevented the effects of melatonin on cell differentiation but was without effect when administered to saline treated hamsters alone. Both the relative number of mitoses and the number of total cells, estimated by counting the nuclei, was not affected. Thus, a conversion from Type I to Type II cells seems possible. The effects of melatonin and NMDA administration were independent of the serum levels of testosterone, luteinizing hormone and thyroxine, hormones which have been implicated in Type II cell differentiation. However, prolactin levels, which were affected by melatonin and NMDA administration, might be involved in the differentiation of Harderian gland secretory cells.

Original languageEnglish (US)
Pages (from-to)101-111
Number of pages11
JournalEndocrine Research
Volume19
Issue number2-3
DOIs
StatePublished - 1993

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Harderian Gland
Melatonin
Aspartic Acid
Cricetinae
Cell Differentiation
N-Methylaspartate
Excitatory Amino Acid Agonists
Mesocricetus
Glutamate Receptors
Luteinizing Hormone
Thyroxine
Mitosis
Prolactin
Testosterone
Cell Count
Hormones
Serum

ASJC Scopus subject areas

  • Endocrinology

Cite this

Chronic n-methyl-d-aspartate administration prevents melatonin-associated changes in cell differentiation in the harderian glands of Male hamsters. / Coto-Montes, Ana M.; Rodriguez-Colunga, Maria J.; Menendez-Pelaez, Armando; Hoover, Pat; Vaughan, Mary K.; Reiter, Russel J.

In: Endocrine Research, Vol. 19, No. 2-3, 1993, p. 101-111.

Research output: Contribution to journalArticle

Coto-Montes, Ana M. ; Rodriguez-Colunga, Maria J. ; Menendez-Pelaez, Armando ; Hoover, Pat ; Vaughan, Mary K. ; Reiter, Russel J. / Chronic n-methyl-d-aspartate administration prevents melatonin-associated changes in cell differentiation in the harderian glands of Male hamsters. In: Endocrine Research. 1993 ; Vol. 19, No. 2-3. pp. 101-111.
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