Chronic mucocutaneous candidiasis. Immunologic studies of three generations of a single family

W. M. Sams, J. L. Jorizzo, R. Snyderman, B. V. Jegasothy, F. E. Ward, Marc H Weiner, J. G. Wilson, W. J. Yount, S. B. Dillard

Research output: Contribution to journalArticle

Abstract

A family consisting of eight members in three generations (age 10 months to 53 years) affected with chronic mucocutaneous candidiasis was studied along with three unaffected relatives. Dermatophytosis, loss of teeth and recurrent viral infections were present in some members. Results of tests for endocrinologic, muscle or liver disease, thymoma, iron deficiency, antitissue antibodies and malabsorption were normal in all patients. Antibody function and levels, B cell counts, serum complement leukocyte enzymes, chemotaxis, phagocytosis and adherence were normal in all members. Plasma inhibitors to lymphocyte transformation and leukocyte inhibitory factor were not found. No unique HLA haplotype or antigen segregated in this family. Evaluation of cell-mediated immunity revealed total cutaneous anergy in three of eight whereas four of the other five had negative lymphocyte transformation and skin tests to Candida but responded normally to other antigens. Leukocyte inhibitory factor was not produced to Candida antigen in all four patients tested. T cell counts were within normal limits in all. Extensive evaluation of all limbs of the immune system in this family revealed a defect in cell-mediated immunity to Candida that appeared to be inherited as a dominant characteristic.

Original languageEnglish (US)
Pages (from-to)948-958
Number of pages11
JournalAmerican Journal of Medicine
Volume67
Issue number6
DOIs
StatePublished - 1979
Externally publishedYes

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Chronic Mucocutaneous Candidiasis
Candida
Lymphocyte Activation
Antigens
Cellular Immunity
Cell Count
Leukocyte Chemotaxis
Tooth Loss
Tinea
Thymoma
Antibodies
Virus Diseases
Skin Tests
Phagocytosis
Haplotypes
Liver Diseases
Immune System
B-Lymphocytes
Extremities
Iron

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Sams, W. M., Jorizzo, J. L., Snyderman, R., Jegasothy, B. V., Ward, F. E., Weiner, M. H., ... Dillard, S. B. (1979). Chronic mucocutaneous candidiasis. Immunologic studies of three generations of a single family. American Journal of Medicine, 67(6), 948-958. https://doi.org/10.1016/0002-9343(79)90659-4

Chronic mucocutaneous candidiasis. Immunologic studies of three generations of a single family. / Sams, W. M.; Jorizzo, J. L.; Snyderman, R.; Jegasothy, B. V.; Ward, F. E.; Weiner, Marc H; Wilson, J. G.; Yount, W. J.; Dillard, S. B.

In: American Journal of Medicine, Vol. 67, No. 6, 1979, p. 948-958.

Research output: Contribution to journalArticle

Sams, WM, Jorizzo, JL, Snyderman, R, Jegasothy, BV, Ward, FE, Weiner, MH, Wilson, JG, Yount, WJ & Dillard, SB 1979, 'Chronic mucocutaneous candidiasis. Immunologic studies of three generations of a single family', American Journal of Medicine, vol. 67, no. 6, pp. 948-958. https://doi.org/10.1016/0002-9343(79)90659-4
Sams, W. M. ; Jorizzo, J. L. ; Snyderman, R. ; Jegasothy, B. V. ; Ward, F. E. ; Weiner, Marc H ; Wilson, J. G. ; Yount, W. J. ; Dillard, S. B. / Chronic mucocutaneous candidiasis. Immunologic studies of three generations of a single family. In: American Journal of Medicine. 1979 ; Vol. 67, No. 6. pp. 948-958.
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