Chronic melatonin treatment prevents age-dependent cardiac mitochondrial dysfunction in senescence-accelerated mice

María I. Rodríguez, Miguel Carretero, Germaine Escames, Luis C. López, María D. Maldonado, Dun Xian Tan, Russel J Reiter, Darío Acuña-Castroviejo

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Heart mitochondria from female senescence-accelerated (SAMP8) and senescence-resistant (SAMR1) mice of 5 or 10 months of age, were studied. Mitochondrial oxidative stress was determined by measuring the levels of lipid peroxidation, glutathione and glutathione disulfide and glutathione peroxidase and reductase activities. Mitochondrial function was assessed by measuring the activity of the respiratory chain complexes and ATP content. The results show that the age-dependent mitochondrial oxidative damage in the heart of SAMP8 mice was accompanied by a reduction in the electron transport chain complex activities and in ATP levels. Chronic melatonin administration between 1 and 10 months of age normalized the redox and the bioenergetic status of the mitochondria and increased ATP levels. The results support the presence of significant mitochondrial oxidative stress in SAM mice at 10 months of age, and they suggest a beneficial effect of chronic pharmacological intervention with melatonin, which reduces the deteriorative and functional oxidative changes in cardiac mitochondria with age.

Original languageEnglish (US)
Pages (from-to)15-24
Number of pages10
JournalFree Radical Research
Volume41
Issue number1
DOIs
StatePublished - Jan 2007

Fingerprint

Mitochondria
Melatonin
Oxidative stress
Adenosine Triphosphate
Electron Transport
Oxidative Stress
Heart Mitochondria
Glutathione Disulfide
Glutathione Reductase
Glutathione Peroxidase
Energy Metabolism
Lipid Peroxidation
Oxidation-Reduction
Glutathione
Pharmacology
Lipids

Keywords

  • Aging
  • Heart
  • Melatonin treatment
  • Mitochondria
  • Oxidative damage

ASJC Scopus subject areas

  • Biochemistry

Cite this

Rodríguez, M. I., Carretero, M., Escames, G., López, L. C., Maldonado, M. D., Tan, D. X., ... Acuña-Castroviejo, D. (2007). Chronic melatonin treatment prevents age-dependent cardiac mitochondrial dysfunction in senescence-accelerated mice. Free Radical Research, 41(1), 15-24. https://doi.org/10.1080/10715760600936359

Chronic melatonin treatment prevents age-dependent cardiac mitochondrial dysfunction in senescence-accelerated mice. / Rodríguez, María I.; Carretero, Miguel; Escames, Germaine; López, Luis C.; Maldonado, María D.; Tan, Dun Xian; Reiter, Russel J; Acuña-Castroviejo, Darío.

In: Free Radical Research, Vol. 41, No. 1, 01.2007, p. 15-24.

Research output: Contribution to journalArticle

Rodríguez, MI, Carretero, M, Escames, G, López, LC, Maldonado, MD, Tan, DX, Reiter, RJ & Acuña-Castroviejo, D 2007, 'Chronic melatonin treatment prevents age-dependent cardiac mitochondrial dysfunction in senescence-accelerated mice', Free Radical Research, vol. 41, no. 1, pp. 15-24. https://doi.org/10.1080/10715760600936359
Rodríguez, María I. ; Carretero, Miguel ; Escames, Germaine ; López, Luis C. ; Maldonado, María D. ; Tan, Dun Xian ; Reiter, Russel J ; Acuña-Castroviejo, Darío. / Chronic melatonin treatment prevents age-dependent cardiac mitochondrial dysfunction in senescence-accelerated mice. In: Free Radical Research. 2007 ; Vol. 41, No. 1. pp. 15-24.
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