Chronic intestinal pseudoobstruction in a patient with heart-lung transplant therapeutic effect of leuprolide acetate

John R. Mathias; Gordon S. Baskin; Vonda G. Reeves-Darby; Mary H. Clench; Lesa L. Smith; John H. Calhoon

doi:10.1007/BF01299872

Chronic intestinal pseudoobstruction in a patient with heart-lung transplant therapeutic effect of leuprolide acetate

John R. Mathias, Gordon S. Baskin, Vonda G. Reeves-Darby, Mary H. Clench, Lesa L. Smith, John H. Calhoon

Department of Cardiothoracic Surgery

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

After orthotopic heart-lung transplantation and immunosuppression, a patient developed intractable nausea and vomiting in association with chronic cytomegalovirus infection. Chronic intestinal pseudoobstruction was documented by antroduodenal manometric study. The patient was treated with leuprolide acetate with resolution of symptoms and improvement of intestinal motility abnormality. This case demonstrates an association of chronic viral infection with acquired intestinal motor disorders. Gastrointestinal complications that are common after organ transplantation might be due to acquired neuromuscular disease. The potential efficacy of leuprolide in such neuromuscular disorders provides a rationale for diagnostic motility studies in patients with "functional" gastrointestinal disorders.

Original language	English (US)
Pages (from-to)	1761-1768
Number of pages	8
Journal	Digestive Diseases and Sciences
Volume	37
Issue number	11
DOIs	https://doi.org/10.1007/BF01299872
State	Published - Nov 1992

Keywords

cytomegalovirus
immunosuppression
intestinal motility
neuromuscular disease

ASJC Scopus subject areas

Gastroenterology
Physiology

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10.1007/BF01299872

Cite this

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title = "Chronic intestinal pseudoobstruction in a patient with heart-lung transplant therapeutic effect of leuprolide acetate",

abstract = "After orthotopic heart-lung transplantation and immunosuppression, a patient developed intractable nausea and vomiting in association with chronic cytomegalovirus infection. Chronic intestinal pseudoobstruction was documented by antroduodenal manometric study. The patient was treated with leuprolide acetate with resolution of symptoms and improvement of intestinal motility abnormality. This case demonstrates an association of chronic viral infection with acquired intestinal motor disorders. Gastrointestinal complications that are common after organ transplantation might be due to acquired neuromuscular disease. The potential efficacy of leuprolide in such neuromuscular disorders provides a rationale for diagnostic motility studies in patients with {"}functional{"} gastrointestinal disorders.",

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AU - Mathias, John R.

AU - Baskin, Gordon S.

AU - Reeves-Darby, Vonda G.

AU - Clench, Mary H.

AU - Smith, Lesa L.

AU - Calhoon, John H.

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AB - After orthotopic heart-lung transplantation and immunosuppression, a patient developed intractable nausea and vomiting in association with chronic cytomegalovirus infection. Chronic intestinal pseudoobstruction was documented by antroduodenal manometric study. The patient was treated with leuprolide acetate with resolution of symptoms and improvement of intestinal motility abnormality. This case demonstrates an association of chronic viral infection with acquired intestinal motor disorders. Gastrointestinal complications that are common after organ transplantation might be due to acquired neuromuscular disease. The potential efficacy of leuprolide in such neuromuscular disorders provides a rationale for diagnostic motility studies in patients with "functional" gastrointestinal disorders.

KW - cytomegalovirus

KW - immunosuppression

KW - intestinal motility

KW - neuromuscular disease

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Chronic intestinal pseudoobstruction in a patient with heart-lung transplant therapeutic effect of leuprolide acetate

Abstract

Keywords

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