Chronic estrogen effects on 5-hydroxytryptamine-mediated responses in hippocampal pyramidal cells of female rats

Sheryl G. Beck; William P. Clarke; Joseph Goldfarb

doi:10.1016/0304-3940(89)90223-1

Chronic estrogen effects on 5-hydroxytryptamine-mediated responses in hippocampal pyramidal cells of female rats

Sheryl G. Beck, William P. Clarke, Joseph Goldfarb

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Intracellular recording techniques were used to assess the effect of chronic estrogen treatment of ovariectomized (OVX) rats on CA1 pyramidal cell properties and serotonin (5-HT)-mediated responses in the dorsal hippocampus. The magnitude of the 5-HT_1A-mediated hyperpolarization and concomitant change in membrane resistance elicited by 15 μM 5-HT was greater in pyramidal cells from OVX rats treated with estrogen (OVX + ES) than in pyramidal cells from OVX rats. Estrogen treatment did not alter the cellular membrane properties or the reduction in AHP amplitude elicited by 15 μM 5-HT. The modulation of 5-HT neurotransmission by estrogen may contribute to variations in mood which are associated with the menstrual cycle.

Original language	English (US)
Pages (from-to)	181-187
Number of pages	7
Journal	Neuroscience Letters
Volume	106
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(89)90223-1
State	Published - Nov 20 1989
Externally published	Yes

Keywords

Afterhyperpolarization
Estrogen
Hippocampus
Hyperpolarization
Intracellular recording
Ovariectomy
Serotonin receptor

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(89)90223-1

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abstract = "Intracellular recording techniques were used to assess the effect of chronic estrogen treatment of ovariectomized (OVX) rats on CA1 pyramidal cell properties and serotonin (5-HT)-mediated responses in the dorsal hippocampus. The magnitude of the 5-HT1A-mediated hyperpolarization and concomitant change in membrane resistance elicited by 15 μM 5-HT was greater in pyramidal cells from OVX rats treated with estrogen (OVX + ES) than in pyramidal cells from OVX rats. Estrogen treatment did not alter the cellular membrane properties or the reduction in AHP amplitude elicited by 15 μM 5-HT. The modulation of 5-HT neurotransmission by estrogen may contribute to variations in mood which are associated with the menstrual cycle.",

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AU - Beck, Sheryl G.

AU - Clarke, William P.

AU - Goldfarb, Joseph

PY - 1989/11/20

Y1 - 1989/11/20

N2 - Intracellular recording techniques were used to assess the effect of chronic estrogen treatment of ovariectomized (OVX) rats on CA1 pyramidal cell properties and serotonin (5-HT)-mediated responses in the dorsal hippocampus. The magnitude of the 5-HT1A-mediated hyperpolarization and concomitant change in membrane resistance elicited by 15 μM 5-HT was greater in pyramidal cells from OVX rats treated with estrogen (OVX + ES) than in pyramidal cells from OVX rats. Estrogen treatment did not alter the cellular membrane properties or the reduction in AHP amplitude elicited by 15 μM 5-HT. The modulation of 5-HT neurotransmission by estrogen may contribute to variations in mood which are associated with the menstrual cycle.

AB - Intracellular recording techniques were used to assess the effect of chronic estrogen treatment of ovariectomized (OVX) rats on CA1 pyramidal cell properties and serotonin (5-HT)-mediated responses in the dorsal hippocampus. The magnitude of the 5-HT1A-mediated hyperpolarization and concomitant change in membrane resistance elicited by 15 μM 5-HT was greater in pyramidal cells from OVX rats treated with estrogen (OVX + ES) than in pyramidal cells from OVX rats. Estrogen treatment did not alter the cellular membrane properties or the reduction in AHP amplitude elicited by 15 μM 5-HT. The modulation of 5-HT neurotransmission by estrogen may contribute to variations in mood which are associated with the menstrual cycle.

KW - Afterhyperpolarization

KW - Estrogen

KW - Hippocampus

KW - Hyperpolarization

KW - Intracellular recording

KW - Ovariectomy

KW - Serotonin receptor

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Chronic estrogen effects on 5-hydroxytryptamine-mediated responses in hippocampal pyramidal cells of female rats

Abstract

Keywords

ASJC Scopus subject areas

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