Chronic estrogen effects on 5-hydroxytryptamine-mediated responses in hippocampal pyramidal cells of female rats

Sheryl G. Beck, William P. Clarke, Joseph Goldfarb

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Intracellular recording techniques were used to assess the effect of chronic estrogen treatment of ovariectomized (OVX) rats on CA1 pyramidal cell properties and serotonin (5-HT)-mediated responses in the dorsal hippocampus. The magnitude of the 5-HT1A-mediated hyperpolarization and concomitant change in membrane resistance elicited by 15 μM 5-HT was greater in pyramidal cells from OVX rats treated with estrogen (OVX + ES) than in pyramidal cells from OVX rats. Estrogen treatment did not alter the cellular membrane properties or the reduction in AHP amplitude elicited by 15 μM 5-HT. The modulation of 5-HT neurotransmission by estrogen may contribute to variations in mood which are associated with the menstrual cycle.

Original languageEnglish (US)
Pages (from-to)181-187
Number of pages7
JournalNeuroscience Letters
Volume106
Issue number1-2
DOIs
StatePublished - Nov 20 1989
Externally publishedYes

Keywords

  • Afterhyperpolarization
  • Estrogen
  • Hippocampus
  • Hyperpolarization
  • Intracellular recording
  • Ovariectomy
  • Serotonin receptor

ASJC Scopus subject areas

  • Neuroscience(all)

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