Abstract
Chronic bronchitis is a clinical entity characterised by chronic bronchial mucus hypersecretion. It is frequently associated with chronic obstructive pulmonary disease (COPD) and it is related to worse outcomes. COPD patients with chronic bronchitis experienced accelerated lung function decline and an increased risk of exacerbations. Chronic mucus hypersecretion is also associated with acute or chronic bacterial bronchial infection, and increased airway and systemic inflammation. In addition, different antibiotic and antiinflammatory treatments have been tested in these patients, with conflicting results. Mechanisms to explain the relationship between chronic bronchitis and infection are not well established, although host factors have been identified as key factors in the pathogenesis of bronchial infection. This chapter discusses the association of chronic bronchitis and the risk of bronchial infection, and the infection mechanisms that are responsible for this association, potential antibiotic and antiinflammatory treatment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 18-26 |
| Number of pages | 9 |
| Journal | European Respiratory Monograph |
| Volume | 60 |
| DOIs | |
| State | Published - 2013 |
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Keywords
- Acute exacerbation
- Airway inflammation
- Bronchial infection
- Chronic bronchitis
- Chronic obstructive pulmonary disease
- Host factors
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Chronic bronchitis : A risk factor for bronchial infection. / Garcia-Bellmunt, Laia; Sibila, Oriol; Restrepo, Marcos; Anzueto, Antonio R.
In: European Respiratory Monograph, Vol. 60, 2013, p. 18-26.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chronic bronchitis
T2 - A risk factor for bronchial infection
AU - Garcia-Bellmunt, Laia
AU - Sibila, Oriol
AU - Restrepo, Marcos
AU - Anzueto, Antonio R
PY - 2013
Y1 - 2013
N2 - Chronic bronchitis is a clinical entity characterised by chronic bronchial mucus hypersecretion. It is frequently associated with chronic obstructive pulmonary disease (COPD) and it is related to worse outcomes. COPD patients with chronic bronchitis experienced accelerated lung function decline and an increased risk of exacerbations. Chronic mucus hypersecretion is also associated with acute or chronic bacterial bronchial infection, and increased airway and systemic inflammation. In addition, different antibiotic and antiinflammatory treatments have been tested in these patients, with conflicting results. Mechanisms to explain the relationship between chronic bronchitis and infection are not well established, although host factors have been identified as key factors in the pathogenesis of bronchial infection. This chapter discusses the association of chronic bronchitis and the risk of bronchial infection, and the infection mechanisms that are responsible for this association, potential antibiotic and antiinflammatory treatment.
AB - Chronic bronchitis is a clinical entity characterised by chronic bronchial mucus hypersecretion. It is frequently associated with chronic obstructive pulmonary disease (COPD) and it is related to worse outcomes. COPD patients with chronic bronchitis experienced accelerated lung function decline and an increased risk of exacerbations. Chronic mucus hypersecretion is also associated with acute or chronic bacterial bronchial infection, and increased airway and systemic inflammation. In addition, different antibiotic and antiinflammatory treatments have been tested in these patients, with conflicting results. Mechanisms to explain the relationship between chronic bronchitis and infection are not well established, although host factors have been identified as key factors in the pathogenesis of bronchial infection. This chapter discusses the association of chronic bronchitis and the risk of bronchial infection, and the infection mechanisms that are responsible for this association, potential antibiotic and antiinflammatory treatment.
KW - Acute exacerbation
KW - Airway inflammation
KW - Bronchial infection
KW - Chronic bronchitis
KW - Chronic obstructive pulmonary disease
KW - Host factors
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UR - http://www.scopus.com/inward/citedby.url?scp=84878436324&partnerID=8YFLogxK
U2 - 10.1183/1025448x.10017012
DO - 10.1183/1025448x.10017012
M3 - Article
VL - 60
SP - 18
EP - 26
JO - European Respiratory Monograph
JF - European Respiratory Monograph
SN - 1025-448X
ER -