Abstract
In the present investigation, infrequent and chronic (daily) exposure of rhesus monkeys to morphine was investigated for their effect on cytokine receptor expression, interleukin (IL)-2 production, and nuclear factor κPB (NFκPB) levels following stimulation with PWM. In a time-dependent manner, peripheral blood mononuclearcells (PBMCs) from both infrequent- and daily-morphine treated monkeys displayed significantly less (40 ± 7% IL-2 receptor compared to PBMCs from saline-treated controls. However, PBMCs from chronic opioid- and infrequent opioidtreated monkeys displayed similar levels of IL-4 and IL-7 receptors compared to saline-treated animals. Following stimulation with PWM, PBMCs from chronic opioid-treated monkeys produced elevated levels of IL-2 (870 ± 94 pg/ml) compared to IL-2 levels (463 ± 88 pg/ml) of PBMCs from saline-treated monkey. Likewise, PBMCs from chronic-morphine exposed monkeys had elevated levels (43% of NFκPB compared to PBMCs from saline-treated (control) monkeys following 72 hours in culture with PWM. Collectively, these observations suggest morphine regulates selective molecular events that manifest in biologically altered immune function including T cell activation and IL-2 production.
Original language | English (US) |
---|---|
Pages (from-to) | 137-148 |
Number of pages | 12 |
Journal | International Journal of Neuroscience |
Volume | 81 |
Issue number | 3-4 |
DOIs | |
State | Published - 1995 |
Externally published | Yes |
Keywords
- Interleukin-2
- Morphine
- NFκPB
- Nuclear factor κPB
- Rhesus monkey
- Tumor necrosis factor- α
ASJC Scopus subject areas
- General Neuroscience