Chronic administration of sublethal doses of carbaryl increases pineal N-acetyltransferase and hydroxyindole-O-methyltransferase activities and serum melatonin levels

A. M. Attia, Russel J Reiter, B. Withyachumnarnkul, M. H. Mostafa, S. A. Soliman, A. K H El-sebae

Research output: Contribution to journalArticle

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Abstract

The purpose of this study was to examine the effects of chronic administration of sublethal doses of carbaryl on pineal melatonin synthesis. N-methyl 1-naphthylcarbamate (cahbaryl) (8.33 mg/kg B.W. daily) was administered orally to adult male albino rats for 6 successive days. Nocturnal (0100) N-acetyltransferase and hydroxyindole-O-methyltransferase activities were increased (roughly 75% and 60%, respectively) by carbaryl administration; likewise, carbaryl augmented serum melatonin levels at 2300. Bineal tryptophan, 5-hydroxytryptophan, serotonin, and 5-hydroxindole acetic acid levels were unaffected at all three time points. The results indicate that the carbamate pesticide, i.e., carbaryl, modifies pineal melatonin synthesis in vivo.

Original languageEnglish (US)
Pages (from-to)49-54
Number of pages6
JournalJournal of Pineal Research
Volume10
Issue number1
StatePublished - 1991

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Acetylserotonin O-Methyltransferase
Carbaryl
Acetyltransferases
Melatonin
Serum
5-Hydroxytryptophan
Carbamates
Pesticides
Tryptophan
Acetic Acid
Serotonin

ASJC Scopus subject areas

  • Endocrinology

Cite this

Chronic administration of sublethal doses of carbaryl increases pineal N-acetyltransferase and hydroxyindole-O-methyltransferase activities and serum melatonin levels. / Attia, A. M.; Reiter, Russel J; Withyachumnarnkul, B.; Mostafa, M. H.; Soliman, S. A.; El-sebae, A. K H.

In: Journal of Pineal Research, Vol. 10, No. 1, 1991, p. 49-54.

Research output: Contribution to journalArticle

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AU - El-sebae, A. K H

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AB - The purpose of this study was to examine the effects of chronic administration of sublethal doses of carbaryl on pineal melatonin synthesis. N-methyl 1-naphthylcarbamate (cahbaryl) (8.33 mg/kg B.W. daily) was administered orally to adult male albino rats for 6 successive days. Nocturnal (0100) N-acetyltransferase and hydroxyindole-O-methyltransferase activities were increased (roughly 75% and 60%, respectively) by carbaryl administration; likewise, carbaryl augmented serum melatonin levels at 2300. Bineal tryptophan, 5-hydroxytryptophan, serotonin, and 5-hydroxindole acetic acid levels were unaffected at all three time points. The results indicate that the carbamate pesticide, i.e., carbaryl, modifies pineal melatonin synthesis in vivo.

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