TY - JOUR
T1 - Chronic administration of sublethal doses of carbaryl increases pineal N‐acetyltransferase and hydroxyindole‐O‐methyltransferase activities and serum melatonin levels
AU - Attia, Ahmed M.
AU - Reiter, Russel J.
AU - Withyachumnarnkul, Boonsirm
AU - Mostafa, Mostafa H.
AU - Soliman, Salah A.
AU - El‐sebae, Abdel‐Khalek H.
PY - 1991/1
Y1 - 1991/1
N2 - Attia AM, Reiter RJ, Withyachumnarnkul B, Mostafa MH, Soliman SA, El‐sebae A.‐K.H. Chronic administration of sublethal doses of carbaryl increases pineal N‐acetyltransferase and hydroxy‐0‐ rnethyltransferase activities and serum melatonin levels. J Pineal Res 1 99 1 1 0149‐54. The purpose of this study was to examine the effects of chronic administration of sublethal doses of carbaryl on pineal melatonin synthesis. N‐methyl 1‐naphthylcarbamate (carbaryl) (8.33 mg/kg B.W. daily) was administered orally to adult male albino rats for 6 successive days. Nocturnal (0100) N‐acetyltransferase and hydroxyindole‐0‐methyltransferase activities were increased (roughly 75% and 60%, respectively) by carbaryl administration; likewise, carbaryl augmented serum melatonin levels at 2300. Pineal tryptophan, 5‐hydroxytryptophan, serotonin, and 5‐hydroxindole acetic acid levels were unaffected at all three time points. The results indicate that the carbamate pesticide, i.e., carbaryl, modifies pineal melatonin synthesis in vivo.
AB - Attia AM, Reiter RJ, Withyachumnarnkul B, Mostafa MH, Soliman SA, El‐sebae A.‐K.H. Chronic administration of sublethal doses of carbaryl increases pineal N‐acetyltransferase and hydroxy‐0‐ rnethyltransferase activities and serum melatonin levels. J Pineal Res 1 99 1 1 0149‐54. The purpose of this study was to examine the effects of chronic administration of sublethal doses of carbaryl on pineal melatonin synthesis. N‐methyl 1‐naphthylcarbamate (carbaryl) (8.33 mg/kg B.W. daily) was administered orally to adult male albino rats for 6 successive days. Nocturnal (0100) N‐acetyltransferase and hydroxyindole‐0‐methyltransferase activities were increased (roughly 75% and 60%, respectively) by carbaryl administration; likewise, carbaryl augmented serum melatonin levels at 2300. Pineal tryptophan, 5‐hydroxytryptophan, serotonin, and 5‐hydroxindole acetic acid levels were unaffected at all three time points. The results indicate that the carbamate pesticide, i.e., carbaryl, modifies pineal melatonin synthesis in vivo.
KW - Key words: pineal gland—melatonin, in serum and pineal—indoleamine metabolism—carbaryl—pesticide
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U2 - 10.1111/j.1600-079X.1991.tb00009.x
DO - 10.1111/j.1600-079X.1991.tb00009.x
M3 - Article
C2 - 1711578
AN - SCOPUS:0025906449
VL - 10
SP - 49
EP - 54
JO - Journal of Pineal Research
JF - Journal of Pineal Research
SN - 0742-3098
IS - 1
ER -