Abstract
The purpose of this study was to examine the effects of chronic administration of sublethal doses of carbaryl on pineal melatonin synthesis. N-methyl 1-naphthylcarbamate (cahbaryl) (8.33 mg/kg B.W. daily) was administered orally to adult male albino rats for 6 successive days. Nocturnal (0100) N-acetyltransferase and hydroxyindole-O-methyltransferase activities were increased (roughly 75% and 60%, respectively) by carbaryl administration; likewise, carbaryl augmented serum melatonin levels at 2300. Bineal tryptophan, 5-hydroxytryptophan, serotonin, and 5-hydroxindole acetic acid levels were unaffected at all three time points. The results indicate that the carbamate pesticide, i.e., carbaryl, modifies pineal melatonin synthesis in vivo.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 49-54 |
| Number of pages | 6 |
| Journal | Journal of Pineal Research |
| Volume | 10 |
| Issue number | 1 |
| State | Published - 1991 |
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ASJC Scopus subject areas
- Endocrinology
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Chronic administration of sublethal doses of carbaryl increases pineal N-acetyltransferase and hydroxyindole-O-methyltransferase activities and serum melatonin levels. / Attia, A. M.; Reiter, Russel J; Withyachumnarnkul, B.; Mostafa, M. H.; Soliman, S. A.; El-sebae, A. K H.
In: Journal of Pineal Research, Vol. 10, No. 1, 1991, p. 49-54.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chronic administration of sublethal doses of carbaryl increases pineal N-acetyltransferase and hydroxyindole-O-methyltransferase activities and serum melatonin levels
AU - Attia, A. M.
AU - Reiter, Russel J
AU - Withyachumnarnkul, B.
AU - Mostafa, M. H.
AU - Soliman, S. A.
AU - El-sebae, A. K H
PY - 1991
Y1 - 1991
N2 - The purpose of this study was to examine the effects of chronic administration of sublethal doses of carbaryl on pineal melatonin synthesis. N-methyl 1-naphthylcarbamate (cahbaryl) (8.33 mg/kg B.W. daily) was administered orally to adult male albino rats for 6 successive days. Nocturnal (0100) N-acetyltransferase and hydroxyindole-O-methyltransferase activities were increased (roughly 75% and 60%, respectively) by carbaryl administration; likewise, carbaryl augmented serum melatonin levels at 2300. Bineal tryptophan, 5-hydroxytryptophan, serotonin, and 5-hydroxindole acetic acid levels were unaffected at all three time points. The results indicate that the carbamate pesticide, i.e., carbaryl, modifies pineal melatonin synthesis in vivo.
AB - The purpose of this study was to examine the effects of chronic administration of sublethal doses of carbaryl on pineal melatonin synthesis. N-methyl 1-naphthylcarbamate (cahbaryl) (8.33 mg/kg B.W. daily) was administered orally to adult male albino rats for 6 successive days. Nocturnal (0100) N-acetyltransferase and hydroxyindole-O-methyltransferase activities were increased (roughly 75% and 60%, respectively) by carbaryl administration; likewise, carbaryl augmented serum melatonin levels at 2300. Bineal tryptophan, 5-hydroxytryptophan, serotonin, and 5-hydroxindole acetic acid levels were unaffected at all three time points. The results indicate that the carbamate pesticide, i.e., carbaryl, modifies pineal melatonin synthesis in vivo.
UR - http://www.scopus.com/inward/record.url?scp=0025906449&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025906449&partnerID=8YFLogxK
M3 - Article
VL - 10
SP - 49
EP - 54
JO - Journal of Pineal Research
JF - Journal of Pineal Research
SN - 0742-3098
IS - 1
ER -