Chronic 1,4-butanediol treatment in rats: Cross-tolerance to γ-hydroxybutyrate and (±)-baclofen

Kary A. Eckermann; Wouter Koek; Charles P. France

doi:10.1016/j.ejphar.2003.11.016

Chronic 1,4-butanediol treatment in rats: Cross-tolerance to γ-hydroxybutyrate and (±)-baclofen

Kary A. Eckermann
, Wouter Koek
, Charles P. France

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The effects of 1,4-butanediol, γ-hydroxybutyrate (GHB), and (±)-baclofen on food-maintained responding in rats were assessed before, during, and after chronic treatment with 1,4-butanediol. Six weeks of treatment with 1,4-butanediol (twice daily, 320 mg/kg for 3 weeks followed by 560 mg/kg for 3 weeks) decreased sensitivity to the rate-decreasing effects of (±)-baclofen and GHB without changing sensitivity to 1,4-butanediol. Sensitivity to (±)-baclofen and GHB returned to control values 2-3 weeks after discontinuation of treatment. These data suggest that tolerance to the effects of GHB or its precursors might result from changes in GABA_B mechanisms.

Original language	English (US)
Pages (from-to)	259-262
Number of pages	4
Journal	European Journal of Pharmacology
Volume	484
Issue number	2-3
DOIs	https://doi.org/10.1016/j.ejphar.2003.11.016
State	Published - Jan 26 2004

Keywords

(±)-Baclofen
1,4-Butanediol
Cross-tolerance
GABA receptor
γ-GHB (γ-hydroxybutyrate)

ASJC Scopus subject areas

Pharmacology

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10.1016/j.ejphar.2003.11.016

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title = "Chronic 1,4-butanediol treatment in rats: Cross-tolerance to γ-hydroxybutyrate and (±)-baclofen",

abstract = "The effects of 1,4-butanediol, γ-hydroxybutyrate (GHB), and (±)-baclofen on food-maintained responding in rats were assessed before, during, and after chronic treatment with 1,4-butanediol. Six weeks of treatment with 1,4-butanediol (twice daily, 320 mg/kg for 3 weeks followed by 560 mg/kg for 3 weeks) decreased sensitivity to the rate-decreasing effects of (±)-baclofen and GHB without changing sensitivity to 1,4-butanediol. Sensitivity to (±)-baclofen and GHB returned to control values 2-3 weeks after discontinuation of treatment. These data suggest that tolerance to the effects of GHB or its precursors might result from changes in GABAB mechanisms.",

keywords = "(±)-Baclofen, 1,4-Butanediol, Cross-tolerance, GABA receptor, γ-GHB (γ-hydroxybutyrate)",

author = "Eckermann, \{Kary A.\} and Wouter Koek and France, \{Charles P.\}",

note = "Funding Information: Supported by USPHS DA14986 and RCA DA0211 (CPF). The authors thank Dr. L.R. McMahon and L.P. Carter for helpful suggestions as well as C. Cruz, H. Renteria, D. Mojica, and G. Phillips for excellent technical assistance.",

year = "2004",

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day = "26",

doi = "10.1016/j.ejphar.2003.11.016",

language = "English (US)",

volume = "484",

pages = "259--262",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

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T1 - Chronic 1,4-butanediol treatment in rats

T2 - Cross-tolerance to γ-hydroxybutyrate and (±)-baclofen

AU - Eckermann, Kary A.

AU - Koek, Wouter

AU - France, Charles P.

N1 - Funding Information: Supported by USPHS DA14986 and RCA DA0211 (CPF). The authors thank Dr. L.R. McMahon and L.P. Carter for helpful suggestions as well as C. Cruz, H. Renteria, D. Mojica, and G. Phillips for excellent technical assistance.

PY - 2004/1/26

Y1 - 2004/1/26

N2 - The effects of 1,4-butanediol, γ-hydroxybutyrate (GHB), and (±)-baclofen on food-maintained responding in rats were assessed before, during, and after chronic treatment with 1,4-butanediol. Six weeks of treatment with 1,4-butanediol (twice daily, 320 mg/kg for 3 weeks followed by 560 mg/kg for 3 weeks) decreased sensitivity to the rate-decreasing effects of (±)-baclofen and GHB without changing sensitivity to 1,4-butanediol. Sensitivity to (±)-baclofen and GHB returned to control values 2-3 weeks after discontinuation of treatment. These data suggest that tolerance to the effects of GHB or its precursors might result from changes in GABAB mechanisms.

AB - The effects of 1,4-butanediol, γ-hydroxybutyrate (GHB), and (±)-baclofen on food-maintained responding in rats were assessed before, during, and after chronic treatment with 1,4-butanediol. Six weeks of treatment with 1,4-butanediol (twice daily, 320 mg/kg for 3 weeks followed by 560 mg/kg for 3 weeks) decreased sensitivity to the rate-decreasing effects of (±)-baclofen and GHB without changing sensitivity to 1,4-butanediol. Sensitivity to (±)-baclofen and GHB returned to control values 2-3 weeks after discontinuation of treatment. These data suggest that tolerance to the effects of GHB or its precursors might result from changes in GABAB mechanisms.

KW - (±)-Baclofen

KW - 1,4-Butanediol

KW - Cross-tolerance

KW - GABA receptor

KW - γ-GHB (γ-hydroxybutyrate)

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UR - https://www.scopus.com/pages/publications/1642505607#tab=citedBy

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M3 - Article

C2 - 14744611

AN - SCOPUS:1642505607

SN - 0014-2999

VL - 484

SP - 259

EP - 262

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 2-3

ER -

Chronic 1,4-butanediol treatment in rats: Cross-tolerance to γ-hydroxybutyrate and (±)-baclofen

Abstract

Keywords

ASJC Scopus subject areas

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